Possible mechanisms behind cardiac troponin elevations

Ola Hammarsten, Johannes Mair, Martin Möckel, Bertil Lindahl, Allan S Jaffe

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Abstract: Cardiac-specific troponins are elevated in blood following cardiac injury and are the preferred diagnostic biomarkers when acute myocardial infarction is suspected clinically. Cardiac troponin (cTn) elevations are also observed in clinical conditions without obvious connection to cardiac injury. Irrespective of the underlying condition, cTn elevation is linked to a poor prognosis, even if the elevation is stable over time. Here, we explore mechanisms that may lead to cTn elevations, including necrosis, apoptosis, necroptosis, cell wounds and decreased clearance. The aim is to broaden the perspective of how we interpret unexpected cTn elevations in patients. The cTn elevations may not be able to serve as direct proof of myocardial necrosis especially in the absence of a clear-cut reason for its release. Abbreviations: AMI: acute myocardial infarction; cTn: cardiac troponin; cTnI: cardiac troponin I; cTnT: cardiac troponin T; MLKL: mixed lineage kinase domain-like; TUNEL: terminal deoxynucleotidyl transferase nick end labeling.

Original languageEnglish (US)
Pages (from-to)725-734
Number of pages10
JournalBiomarkers
Volume23
Issue number8
DOIs
StatePublished - Nov 17 2018

Fingerprint

Troponin
Wounds and Injuries
Necrosis
Myocardial Infarction
Troponin T
Troponin I
DNA Nucleotidylexotransferase
In Situ Nick-End Labeling
Biomarkers
Labeling
Blood
Phosphotransferases
Apoptosis

Keywords

  • apoptosis
  • Cardiac troponin I
  • cardiac troponin T
  • clearance
  • myocardial injury
  • necrosis
  • release
  • reversible

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Possible mechanisms behind cardiac troponin elevations. / Hammarsten, Ola; Mair, Johannes; Möckel, Martin; Lindahl, Bertil; Jaffe, Allan S.

In: Biomarkers, Vol. 23, No. 8, 17.11.2018, p. 725-734.

Research output: Contribution to journalReview article

Hammarsten, O, Mair, J, Möckel, M, Lindahl, B & Jaffe, AS 2018, 'Possible mechanisms behind cardiac troponin elevations', Biomarkers, vol. 23, no. 8, pp. 725-734. https://doi.org/10.1080/1354750X.2018.1490969
Hammarsten, Ola ; Mair, Johannes ; Möckel, Martin ; Lindahl, Bertil ; Jaffe, Allan S. / Possible mechanisms behind cardiac troponin elevations. In: Biomarkers. 2018 ; Vol. 23, No. 8. pp. 725-734.
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