Possible HLA influence in governing susceptibility to non-cirrhotic portal fibrosis

Veena D Taneja, N. K. Mehra, S. K. Sarin, B. K. Sharma, M. C. Vaidya

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Forty-eight unrelated North Indian patients with non-cirrhotic portal fibrosis were studied for the distribution of HLA-A, B and DR antigens. No significant differences were observed in the distribution of HLA-A and B locus antigens. In the DR locus, the frequency of DR3 was significantly increased in the patients as compared to the controls (71.7% vs 26.1%, X2 = 25.3), while HLA-DR2 was significantly reduced (X2 = 11.3). Another striking observation was the presence of DR7 in all males negative for HLA-DR3. The results suggest an autoimmune pathogenesis of the disease and that susceptibility to non-cirrhotic portal fibrosis may be HLA class II mediated, with HLA-DR3 influencing susceptibility and DR2 conferring protection. Other genetic factors are also involved.

Original languageEnglish (US)
Pages (from-to)184-187
Number of pages4
JournalTissue Antigens
Volume30
Issue number4
StatePublished - 1987
Externally publishedYes

Fingerprint

HLA-DR3 Antigen
HLA-A Antigens
HLA-B Antigens
Fibrosis
HLA-DR2 Antigen
Disease Susceptibility
HLA-DR Antigens
Autoimmune Diseases
Observation
Antigens

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Taneja, V. D., Mehra, N. K., Sarin, S. K., Sharma, B. K., & Vaidya, M. C. (1987). Possible HLA influence in governing susceptibility to non-cirrhotic portal fibrosis. Tissue Antigens, 30(4), 184-187.

Possible HLA influence in governing susceptibility to non-cirrhotic portal fibrosis. / Taneja, Veena D; Mehra, N. K.; Sarin, S. K.; Sharma, B. K.; Vaidya, M. C.

In: Tissue Antigens, Vol. 30, No. 4, 1987, p. 184-187.

Research output: Contribution to journalArticle

Taneja, VD, Mehra, NK, Sarin, SK, Sharma, BK & Vaidya, MC 1987, 'Possible HLA influence in governing susceptibility to non-cirrhotic portal fibrosis', Tissue Antigens, vol. 30, no. 4, pp. 184-187.
Taneja, Veena D ; Mehra, N. K. ; Sarin, S. K. ; Sharma, B. K. ; Vaidya, M. C. / Possible HLA influence in governing susceptibility to non-cirrhotic portal fibrosis. In: Tissue Antigens. 1987 ; Vol. 30, No. 4. pp. 184-187.
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