Moglichkeiten der Gentherapie bei traumatischen und degenerativen Gelenklasionen. Aktueller Stand experimenteller und erster klinischer Anwendungen

Translated title of the contribution: Possibilities of gene therapy in traumatic and degenerative lesions of the joints. Current experimental status and preliminary clinical applications

T. G. Gerich, P. Lobenhoffer, F. H. Fu, P. D. Robbins, Christopher H Evans

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Soft tissue injuries often represent the greatest clinical problem. Not only do many of the most frequently injured tissues, such as the cruciate ligaments and articular cartilage, have very limited capabilities for spontaneous repair, but they also respond poorly to surgical or non-surgical intervention. In this article we try to define the role of growth factors in these conditions and to outline concepts for future treatment based upon modulation of the native repair response. We suggest that gene transfer could improve the management of such injuries, particularly when used as vehicles for the targetted delivery of growth factors.

Translated title of the contributionPossibilities of gene therapy in traumatic and degenerative lesions of the joints. Current experimental status and preliminary clinical applications
Original languageGerman
Pages (from-to)450-458
Number of pages9
JournalOrthopade
Volume26
Issue number5
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Keywords

  • adenovirus
  • gene-transfer
  • liposomes
  • retrovirus

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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