Positive Fluid Balance is Associated with Poor Outcomes in Subarachnoid Hemorrhage

Narayan R. Kissoon, Jayawant Mandrekar, Jennifer E. Fugate, Giuseppe Lanzino, Eelco F M Wijdicks, Alejandro Rabinstein

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background Strict maintenance of normovolemia is standard of care in the treatment of aneurysmal subarachnoid hemorrhage (aSAH), and induced hypervolemia is often used to treat delayed cerebral ischemia from vasospasm. We tested the hypothesis that positive fluid balance could adversely affect clinical outcomes in aSAH. Methods We reviewed 288 patients with aSAH admitted to the Neuroscience Intensive Care Unit (NICU) from October 2001 to June 2011. We collected data on fluid balance during NICU stay, clinical and radiographic evidence of vasospasm, cardiopulmonary complications, and functional outcomes by modified Rankin Scale (mRS) on follow-up (mean 8 ± 8 months). Poor functional outcome was defined as an mRS score 3-6. Associations of variables of interest with outcome were assessed using univariable and multivariable logistic regression. Propensity scores were estimated to account for imbalances between patients with positive versus negative fluid balance and were included in multivariable models. Results Average net fluid balance during the NICU stay was greater in patients with poor functional outcome (3.52 ± 5.51 L versus -.02 ± 5.30 L in patients with good outcome; P

Original languageEnglish (US)
Pages (from-to)2245-2251
Number of pages7
JournalJournal of Stroke and Cerebrovascular Diseases
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2015

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Water-Electrolyte Balance
Subarachnoid Hemorrhage
Neurosciences
Intensive Care Units
Intracranial Vasospasm
Propensity Score
Standard of Care
Brain Ischemia
Logistic Models
Maintenance
Therapeutics

Keywords

  • balance
  • fluids
  • outcome
  • prognosis
  • Subarachnoid hemorrhage

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Rehabilitation
  • Cardiology and Cardiovascular Medicine

Cite this

Positive Fluid Balance is Associated with Poor Outcomes in Subarachnoid Hemorrhage. / Kissoon, Narayan R.; Mandrekar, Jayawant; Fugate, Jennifer E.; Lanzino, Giuseppe; Wijdicks, Eelco F M; Rabinstein, Alejandro.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 24, No. 10, 01.10.2015, p. 2245-2251.

Research output: Contribution to journalArticle

Kissoon, Narayan R. ; Mandrekar, Jayawant ; Fugate, Jennifer E. ; Lanzino, Giuseppe ; Wijdicks, Eelco F M ; Rabinstein, Alejandro. / Positive Fluid Balance is Associated with Poor Outcomes in Subarachnoid Hemorrhage. In: Journal of Stroke and Cerebrovascular Diseases. 2015 ; Vol. 24, No. 10. pp. 2245-2251.
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