Positive association between ATP2B1 rs17249754 and essential hypertension: A case-control study in Burkina Faso, West Africa

Herman Karim Sombié, Jonas Koudougou Kologo, Daméhan Tchelougou, Serge Yannick Ouédraogo, Abdoul Karim Ouattara, Tegwindé Rebecca Compaoré, Bolni Nagalo, Abel Pegdwendé Sorgho, Issoufou Nagabila, Serge Théophile Soubeïga, Florencia Wendkuuni Djigma, Albert Théophane Yonli, Patrice Zabsonré, Hassanata Millogo, Jacques Simporé

Research output: Contribution to journalArticle

Abstract

Background: Genetic and environment play a significant role in the etiology of essential hypertension (EH). Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension. In this study we aimed to determine firstly whether index variants were associated with the risk of developing EH in Burkina Faso and secondly to characterize cardiovascular risk markers. Methods: We conducted a case-control study with 380 participants including 180 case subjects with EH and 200 control subjects with normal BP. We used TaqMan genotyping assays with probes from Applied Biosystems to genotype polymorphisms using the 7500 Real-Time PCR System. Biochemical parameters were measured using chemistry analyzer COBAS C311. Results: T-test showed that cardiovascular risk markers such as body mass index, waist circumference, blood sugar, total cholesterol and triglycerides were significantly higher in hypertensive compared to normotensive (all p < 0.05). Binary logistic regression analysis revealed in decreasing order that overweight, family history of hypertension, central obesity and alcohol intake increased the risk of developing EH (all OR > 3.8; all p < 0.001). In genetic level we observed that individuals carrying the AA+AG genotype of ATP2B1 rs17249754 had a low risk of developing EH than those carrying the GG genotype (OR = 0.48 [95% CI: 0.31-0.75] p = 0.001) and the A allele frequency in the cases was significantly lower than that of the controls (OR = 0.56 [95% CI: 0.38-0.82] p = 0.003). We also observed that ATP2B1 rs17249754 was significantly associated with higher SBP and DPB in case and control groups (GG versus AG + AA; p < 0.05), ATP2B1 rs2681472 was significantly associated with higher SBP only in case and control group (AA versus AG + GG; p < 0.05), STK39 rs3754777 was not significantly associated with any of the BP traits (CC versus CT + TT; p > 0.05). Conclusion: Our results confirmed the significant association of ATP2B1 rs17249754 with the risk of developing EH in Burkinabe and showed an increase of cardiovascular risk markers levels in subjects with EH.

Original languageEnglish (US)
Article number155
JournalBMC Cardiovascular Disorders
Volume19
Issue number1
DOIs
StatePublished - Jun 26 2019
Externally publishedYes

Fingerprint

Burkina Faso
Western Africa
Case-Control Studies
Computer Systems
Waist Circumference
Blood Glucose
Real-Time Polymerase Chain Reaction
Triglycerides
Body Mass Index
Cholesterol
Genotype
Essential Hypertension
Hypertension

Keywords

  • ATP2B1
  • Burkina Faso
  • Essential hypertension
  • STK39

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sombié, H. K., Kologo, J. K., Tchelougou, D., Ouédraogo, S. Y., Ouattara, A. K., Compaoré, T. R., ... Simporé, J. (2019). Positive association between ATP2B1 rs17249754 and essential hypertension: A case-control study in Burkina Faso, West Africa. BMC Cardiovascular Disorders, 19(1), [155]. https://doi.org/10.1186/s12872-019-1136-x

Positive association between ATP2B1 rs17249754 and essential hypertension : A case-control study in Burkina Faso, West Africa. / Sombié, Herman Karim; Kologo, Jonas Koudougou; Tchelougou, Daméhan; Ouédraogo, Serge Yannick; Ouattara, Abdoul Karim; Compaoré, Tegwindé Rebecca; Nagalo, Bolni; Sorgho, Abel Pegdwendé; Nagabila, Issoufou; Soubeïga, Serge Théophile; Djigma, Florencia Wendkuuni; Yonli, Albert Théophane; Zabsonré, Patrice; Millogo, Hassanata; Simporé, Jacques.

In: BMC Cardiovascular Disorders, Vol. 19, No. 1, 155, 26.06.2019.

Research output: Contribution to journalArticle

Sombié, HK, Kologo, JK, Tchelougou, D, Ouédraogo, SY, Ouattara, AK, Compaoré, TR, Nagalo, B, Sorgho, AP, Nagabila, I, Soubeïga, ST, Djigma, FW, Yonli, AT, Zabsonré, P, Millogo, H & Simporé, J 2019, 'Positive association between ATP2B1 rs17249754 and essential hypertension: A case-control study in Burkina Faso, West Africa', BMC Cardiovascular Disorders, vol. 19, no. 1, 155. https://doi.org/10.1186/s12872-019-1136-x
Sombié, Herman Karim ; Kologo, Jonas Koudougou ; Tchelougou, Daméhan ; Ouédraogo, Serge Yannick ; Ouattara, Abdoul Karim ; Compaoré, Tegwindé Rebecca ; Nagalo, Bolni ; Sorgho, Abel Pegdwendé ; Nagabila, Issoufou ; Soubeïga, Serge Théophile ; Djigma, Florencia Wendkuuni ; Yonli, Albert Théophane ; Zabsonré, Patrice ; Millogo, Hassanata ; Simporé, Jacques. / Positive association between ATP2B1 rs17249754 and essential hypertension : A case-control study in Burkina Faso, West Africa. In: BMC Cardiovascular Disorders. 2019 ; Vol. 19, No. 1.
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abstract = "Background: Genetic and environment play a significant role in the etiology of essential hypertension (EH). Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension. In this study we aimed to determine firstly whether index variants were associated with the risk of developing EH in Burkina Faso and secondly to characterize cardiovascular risk markers. Methods: We conducted a case-control study with 380 participants including 180 case subjects with EH and 200 control subjects with normal BP. We used TaqMan genotyping assays with probes from Applied Biosystems to genotype polymorphisms using the 7500 Real-Time PCR System. Biochemical parameters were measured using chemistry analyzer COBAS C311. Results: T-test showed that cardiovascular risk markers such as body mass index, waist circumference, blood sugar, total cholesterol and triglycerides were significantly higher in hypertensive compared to normotensive (all p < 0.05). Binary logistic regression analysis revealed in decreasing order that overweight, family history of hypertension, central obesity and alcohol intake increased the risk of developing EH (all OR > 3.8; all p < 0.001). In genetic level we observed that individuals carrying the AA+AG genotype of ATP2B1 rs17249754 had a low risk of developing EH than those carrying the GG genotype (OR = 0.48 [95{\%} CI: 0.31-0.75] p = 0.001) and the A allele frequency in the cases was significantly lower than that of the controls (OR = 0.56 [95{\%} CI: 0.38-0.82] p = 0.003). We also observed that ATP2B1 rs17249754 was significantly associated with higher SBP and DPB in case and control groups (GG versus AG + AA; p < 0.05), ATP2B1 rs2681472 was significantly associated with higher SBP only in case and control group (AA versus AG + GG; p < 0.05), STK39 rs3754777 was not significantly associated with any of the BP traits (CC versus CT + TT; p > 0.05). Conclusion: Our results confirmed the significant association of ATP2B1 rs17249754 with the risk of developing EH in Burkinabe and showed an increase of cardiovascular risk markers levels in subjects with EH.",
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T1 - Positive association between ATP2B1 rs17249754 and essential hypertension

T2 - A case-control study in Burkina Faso, West Africa

AU - Sombié, Herman Karim

AU - Kologo, Jonas Koudougou

AU - Tchelougou, Daméhan

AU - Ouédraogo, Serge Yannick

AU - Ouattara, Abdoul Karim

AU - Compaoré, Tegwindé Rebecca

AU - Nagalo, Bolni

AU - Sorgho, Abel Pegdwendé

AU - Nagabila, Issoufou

AU - Soubeïga, Serge Théophile

AU - Djigma, Florencia Wendkuuni

AU - Yonli, Albert Théophane

AU - Zabsonré, Patrice

AU - Millogo, Hassanata

AU - Simporé, Jacques

PY - 2019/6/26

Y1 - 2019/6/26

N2 - Background: Genetic and environment play a significant role in the etiology of essential hypertension (EH). Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension. In this study we aimed to determine firstly whether index variants were associated with the risk of developing EH in Burkina Faso and secondly to characterize cardiovascular risk markers. Methods: We conducted a case-control study with 380 participants including 180 case subjects with EH and 200 control subjects with normal BP. We used TaqMan genotyping assays with probes from Applied Biosystems to genotype polymorphisms using the 7500 Real-Time PCR System. Biochemical parameters were measured using chemistry analyzer COBAS C311. Results: T-test showed that cardiovascular risk markers such as body mass index, waist circumference, blood sugar, total cholesterol and triglycerides were significantly higher in hypertensive compared to normotensive (all p < 0.05). Binary logistic regression analysis revealed in decreasing order that overweight, family history of hypertension, central obesity and alcohol intake increased the risk of developing EH (all OR > 3.8; all p < 0.001). In genetic level we observed that individuals carrying the AA+AG genotype of ATP2B1 rs17249754 had a low risk of developing EH than those carrying the GG genotype (OR = 0.48 [95% CI: 0.31-0.75] p = 0.001) and the A allele frequency in the cases was significantly lower than that of the controls (OR = 0.56 [95% CI: 0.38-0.82] p = 0.003). We also observed that ATP2B1 rs17249754 was significantly associated with higher SBP and DPB in case and control groups (GG versus AG + AA; p < 0.05), ATP2B1 rs2681472 was significantly associated with higher SBP only in case and control group (AA versus AG + GG; p < 0.05), STK39 rs3754777 was not significantly associated with any of the BP traits (CC versus CT + TT; p > 0.05). Conclusion: Our results confirmed the significant association of ATP2B1 rs17249754 with the risk of developing EH in Burkinabe and showed an increase of cardiovascular risk markers levels in subjects with EH.

AB - Background: Genetic and environment play a significant role in the etiology of essential hypertension (EH). Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension. In this study we aimed to determine firstly whether index variants were associated with the risk of developing EH in Burkina Faso and secondly to characterize cardiovascular risk markers. Methods: We conducted a case-control study with 380 participants including 180 case subjects with EH and 200 control subjects with normal BP. We used TaqMan genotyping assays with probes from Applied Biosystems to genotype polymorphisms using the 7500 Real-Time PCR System. Biochemical parameters were measured using chemistry analyzer COBAS C311. Results: T-test showed that cardiovascular risk markers such as body mass index, waist circumference, blood sugar, total cholesterol and triglycerides were significantly higher in hypertensive compared to normotensive (all p < 0.05). Binary logistic regression analysis revealed in decreasing order that overweight, family history of hypertension, central obesity and alcohol intake increased the risk of developing EH (all OR > 3.8; all p < 0.001). In genetic level we observed that individuals carrying the AA+AG genotype of ATP2B1 rs17249754 had a low risk of developing EH than those carrying the GG genotype (OR = 0.48 [95% CI: 0.31-0.75] p = 0.001) and the A allele frequency in the cases was significantly lower than that of the controls (OR = 0.56 [95% CI: 0.38-0.82] p = 0.003). We also observed that ATP2B1 rs17249754 was significantly associated with higher SBP and DPB in case and control groups (GG versus AG + AA; p < 0.05), ATP2B1 rs2681472 was significantly associated with higher SBP only in case and control group (AA versus AG + GG; p < 0.05), STK39 rs3754777 was not significantly associated with any of the BP traits (CC versus CT + TT; p > 0.05). Conclusion: Our results confirmed the significant association of ATP2B1 rs17249754 with the risk of developing EH in Burkinabe and showed an increase of cardiovascular risk markers levels in subjects with EH.

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KW - STK39

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