TY - JOUR
T1 - Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis
AU - Bossuyt, Xavier
AU - Cohen Tervaert, Jan Willem
AU - Arimura, Yoshihiro
AU - Blockmans, Daniel
AU - Flores-Suáez, Luis Felipe
AU - Guillevin, Loïc
AU - Hellmich, Bernhard
AU - Jayne, David
AU - Jennette, J. Charles
AU - Kallenberg, Cees G.M.
AU - Moiseev, Sergey
AU - Novikov, Pavel
AU - Radice, Antonella
AU - Anne Savige, Judith
AU - Alberto Sinico, Renato
AU - Specks, Ulrich
AU - Van Paassen, Pieter
AU - Zhao, Ming Hui
AU - Rasmussen, Niels
AU - Damoiseaux, Jan
AU - Csernok, Elena
N1 - Publisher Copyright:
© 2017 Macmillan Publishers Limited, part of Springer Nature.
PY - 2017
Y1 - 2017
N2 - Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). According to the 1999 international consensus on ANCA testing, indirect immunofluorescence (IIF) should be used to screen for ANCAs, and samples containing ANCAs should then be tested by immunoassays for proteinase 3 (PR3)-ANCAs and myeloperoxidase (MPO)-ANCAs. The distinction between PR3-ANCAs and MPO-ANCAs has important clinical and pathogenic implications. As dependable immunoassays for PR3-ANCAs and MPO-ANCAs have become broadly available, there is increasing international agreement that high-quality immunoassays are the preferred screening method for the diagnosis of ANCA-associated vasculitis. The present Consensus Statement proposes that high-quality immunoassays can be used as the primary screening method for patients suspected of having the ANCA-associated vaculitides GPA and MPA without the categorical need for IIF, and presents and discusses evidence to support this recommendation.
AB - Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). According to the 1999 international consensus on ANCA testing, indirect immunofluorescence (IIF) should be used to screen for ANCAs, and samples containing ANCAs should then be tested by immunoassays for proteinase 3 (PR3)-ANCAs and myeloperoxidase (MPO)-ANCAs. The distinction between PR3-ANCAs and MPO-ANCAs has important clinical and pathogenic implications. As dependable immunoassays for PR3-ANCAs and MPO-ANCAs have become broadly available, there is increasing international agreement that high-quality immunoassays are the preferred screening method for the diagnosis of ANCA-associated vasculitis. The present Consensus Statement proposes that high-quality immunoassays can be used as the primary screening method for patients suspected of having the ANCA-associated vaculitides GPA and MPA without the categorical need for IIF, and presents and discusses evidence to support this recommendation.
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U2 - 10.1038/nrrheum.2017.140
DO - 10.1038/nrrheum.2017.140
M3 - Article
C2 - 28905856
AN - SCOPUS:85032643949
SN - 1759-4790
VL - 13
SP - 683
EP - 692
JO - Nature Reviews Rheumatology
JF - Nature Reviews Rheumatology
IS - 11
ER -