Portopulmonary hypertension

Rodrigo Cartin-Ceba, Michael J. Krowka

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Portopulmonary hypertension (POPH) is the presence of pulmonary arterial hypertension in patients with portal hypertension. Among liver transplant (LT) candidates, reported incidence rates of POPH range from 4.5% to 8.5%. In patients with LT, intraoperative death and immediate post-LT mortality are feared clinical events when transplantation is attempted in the setting of untreated, moderate to severe POPH; therefore, POPH precludes LT unless the mean pulmonary artery pressure can be reduced to a safe level and right ventricular function optimized. Specific pulmonary artery vasodilator medications seem effective in reducing pulmonary artery pressures and improving right ventricular function and survival.

Original languageEnglish (US)
Pages (from-to)421-438
Number of pages18
JournalClinics in liver disease
Volume18
Issue number2
DOIs
StatePublished - May 2014

Keywords

  • Cirrhosis
  • Liver transplant
  • Portal hypertension
  • Portopulmonary hypertension
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Hepatology

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