Portal hypertension correlates with splenic stiffness as measured with MR elastography

Geir I. Nedredal, Meng Yin, Travis McKenzie, Joseph Lillegard, Jennifer Luebke-Wheeler, Jayant Talwalkar, Richard Lorne Ehman, Scott Nyberg

Research output: Contribution to journalArticle

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Abstract

Purpose: To investigate the correlation between MR elastography (MRE) assessed spleen stiffness and direct portal vein pressure gradient (D-HVPG) measurements in a large animal model of portal hypertension. Materials and Methods: Cholestatic liver disease was established in adult canines by common bile duct ligation. A spin echo based echo planar imaging (EPI) MRE sequence was used to acquire three-dimensional/three axis (3D/3-axis) abdominal MRE data at baseline, 4 weeks, and 8 weeks. Liver biopsies, blood samples, and D-HVPG measurements were obtained simultaneously. Results: Animals developed portal hypertension (D-HVPG: 11.0 ± 5.1 mmHg) with only F1 fibrosis after 4 weeks. F3 fibrosis was confirmed after 8 weeks despite no further rise in portal hypertension (D-HVPG: 11.3 ± 3.2 mmHg). Mean stiffnesses of the spleen increased over two-fold from baseline (1.72 ± 0.33 kPa) to 4 weeks (3.54 ± 0.31 kPa), and stabilized at 8 weeks (3.38 ± 0.06 kPa) in a pattern consistent with changes in portal pressure. A positive correlation was observed between spleen stiffness and D-HVPG (r 2 = 0.86; P < 0.01). Conclusion: These findings indicate a temporal relationship between portal hypertension and the development of liver fibrosis in a large animal model of cholestatic liver disease. The observed direct correlation between spleen stiffness and D-HVPG suggest a noninvasive MRE approach to diagnose and screen for portal hypertension.

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume34
Issue number1
DOIs
StatePublished - Jul 2011

Fingerprint

Elasticity Imaging Techniques
Portal Hypertension
Spleen
Portal Pressure
Liver Diseases
Fibrosis
Animal Models
Echo-Planar Imaging
Common Bile Duct
Portal Vein
Liver Cirrhosis
Ligation
Canidae
Biopsy
Liver

Keywords

  • cirrhosis
  • HVPG
  • magnetic resonance elastography
  • portal hypertension
  • spleen stiffness

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Portal hypertension correlates with splenic stiffness as measured with MR elastography. / Nedredal, Geir I.; Yin, Meng; McKenzie, Travis; Lillegard, Joseph; Luebke-Wheeler, Jennifer; Talwalkar, Jayant; Ehman, Richard Lorne; Nyberg, Scott.

In: Journal of Magnetic Resonance Imaging, Vol. 34, No. 1, 07.2011, p. 79-87.

Research output: Contribution to journalArticle

Nedredal, Geir I. ; Yin, Meng ; McKenzie, Travis ; Lillegard, Joseph ; Luebke-Wheeler, Jennifer ; Talwalkar, Jayant ; Ehman, Richard Lorne ; Nyberg, Scott. / Portal hypertension correlates with splenic stiffness as measured with MR elastography. In: Journal of Magnetic Resonance Imaging. 2011 ; Vol. 34, No. 1. pp. 79-87.
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N2 - Purpose: To investigate the correlation between MR elastography (MRE) assessed spleen stiffness and direct portal vein pressure gradient (D-HVPG) measurements in a large animal model of portal hypertension. Materials and Methods: Cholestatic liver disease was established in adult canines by common bile duct ligation. A spin echo based echo planar imaging (EPI) MRE sequence was used to acquire three-dimensional/three axis (3D/3-axis) abdominal MRE data at baseline, 4 weeks, and 8 weeks. Liver biopsies, blood samples, and D-HVPG measurements were obtained simultaneously. Results: Animals developed portal hypertension (D-HVPG: 11.0 ± 5.1 mmHg) with only F1 fibrosis after 4 weeks. F3 fibrosis was confirmed after 8 weeks despite no further rise in portal hypertension (D-HVPG: 11.3 ± 3.2 mmHg). Mean stiffnesses of the spleen increased over two-fold from baseline (1.72 ± 0.33 kPa) to 4 weeks (3.54 ± 0.31 kPa), and stabilized at 8 weeks (3.38 ± 0.06 kPa) in a pattern consistent with changes in portal pressure. A positive correlation was observed between spleen stiffness and D-HVPG (r 2 = 0.86; P < 0.01). Conclusion: These findings indicate a temporal relationship between portal hypertension and the development of liver fibrosis in a large animal model of cholestatic liver disease. The observed direct correlation between spleen stiffness and D-HVPG suggest a noninvasive MRE approach to diagnose and screen for portal hypertension.

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