TY - JOUR
T1 - Portal Hypertension and Related Complications
T2 - Diagnosis and Management
AU - Simonetto, Douglas A.
AU - Liu, Mengfei
AU - Kamath, Patrick S.
N1 - Publisher Copyright:
© 2019 Mayo Foundation for Medical Education and Research
PY - 2019/4
Y1 - 2019/4
N2 - Portal hypertension is a major complication of cirrhosis, and its consequences, including ascites, esophageal varices, hepatic encephalopathy, and hepatorenal syndrome, lead to substantial morbidity and mortality. The past several decades have seen major improvements in the clinical management of complications of portal hypertension, resulting in substantial gains in patient outcomes. However, important challenges remain. This review focuses on the pathophysiology and diagnosis of portal hypertension and discusses general approaches in the management of patients with ascites as a result of portal hypertension.
AB - Portal hypertension is a major complication of cirrhosis, and its consequences, including ascites, esophageal varices, hepatic encephalopathy, and hepatorenal syndrome, lead to substantial morbidity and mortality. The past several decades have seen major improvements in the clinical management of complications of portal hypertension, resulting in substantial gains in patient outcomes. However, important challenges remain. This review focuses on the pathophysiology and diagnosis of portal hypertension and discusses general approaches in the management of patients with ascites as a result of portal hypertension.
UR - http://www.scopus.com/inward/record.url?scp=85063368798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063368798&partnerID=8YFLogxK
U2 - 10.1016/j.mayocp.2018.12.020
DO - 10.1016/j.mayocp.2018.12.020
M3 - Review article
C2 - 30947834
AN - SCOPUS:85063368798
SN - 0025-6196
VL - 94
SP - 714
EP - 726
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 4
ER -