TY - JOUR
T1 - Population screening for barrett esophagus
T2 - A prospective randomized pilot study
AU - Chang, Joseph Y.
AU - Talley, Nicholas J.
AU - Locke, G. Richard
AU - Katzka, David A.
AU - Schleck, Cathy D.
AU - Zinsmeister, Alan R.
AU - Dunagan, Kelly T.
AU - Wu, Tsung Teh
AU - Wang, Kenneth K.
AU - Prasad, Ganapathy A.
N1 - Funding Information:
Supported by a Junior Faculty Development Award from the American College of Gastroenterology (Dr Prasad), NIDDK (RC4DK090413 [Dr Prasad]), Mayo Clinic, Fujinon Inc, and Given Imaging. This project was supported by NIH/NCRR CTSA grant UL1 RR024150 and NIH grant R01 AG034676, to the Rochester Epidemiology Project.
PY - 2011/12
Y1 - 2011/12
N2 - OBJECTIVE: To assess the feasibility of unsedated transnasal endoscopy (uTNE) and video capsule endoscopy (VCE) as alternatives to sedated endoscopy (sEGD) as screening tools for Barrett esophagus (BE) and to obtain preliminary estimates of participation rates for sEGD, uTNE, and VCE when used for community BE screening in a population cohort. PATIENTS AND METHODS: From February 1, 2009, to May 31, 2010, patients from Olmsted County, Minnesota, who were older than 50 years and had no history of known BE were randomized (stratified by age, sex, reflux symptoms noted in a validated questionnaire) into 3 groups for esophageal evaluation with sEGD, uTNE, or VCE. Participation rates and safety profiles were estimated. RESULTS : We contacted 127 patients to recruit 20 for each procedure arm (60 total). The probability of participation was 38% (95% confidence interval [CI], 26%-51%) for sEGD, 50% (95% CI, 35%-65%) for uTNE, and 59% (95% CI, 42%-74%) for VCE. Both uTNE and VCE were well tolerated without adverse effects. BE was identified in 3 patients and esophagitis in 8. CONCLUSION: Unsedated techniques may be acceptable, feasible, and safe alternatives to sEGD to screen for BE in the community. Trial Registration: clinicaltrials.gov Identifier: NCT00943280
AB - OBJECTIVE: To assess the feasibility of unsedated transnasal endoscopy (uTNE) and video capsule endoscopy (VCE) as alternatives to sedated endoscopy (sEGD) as screening tools for Barrett esophagus (BE) and to obtain preliminary estimates of participation rates for sEGD, uTNE, and VCE when used for community BE screening in a population cohort. PATIENTS AND METHODS: From February 1, 2009, to May 31, 2010, patients from Olmsted County, Minnesota, who were older than 50 years and had no history of known BE were randomized (stratified by age, sex, reflux symptoms noted in a validated questionnaire) into 3 groups for esophageal evaluation with sEGD, uTNE, or VCE. Participation rates and safety profiles were estimated. RESULTS : We contacted 127 patients to recruit 20 for each procedure arm (60 total). The probability of participation was 38% (95% confidence interval [CI], 26%-51%) for sEGD, 50% (95% CI, 35%-65%) for uTNE, and 59% (95% CI, 42%-74%) for VCE. Both uTNE and VCE were well tolerated without adverse effects. BE was identified in 3 patients and esophagitis in 8. CONCLUSION: Unsedated techniques may be acceptable, feasible, and safe alternatives to sEGD to screen for BE in the community. Trial Registration: clinicaltrials.gov Identifier: NCT00943280
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U2 - 10.4065/mcp.2011.0396
DO - 10.4065/mcp.2011.0396
M3 - Article
C2 - 22134936
AN - SCOPUS:83155188334
SN - 0025-6196
VL - 86
SP - 1174
EP - 1180
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 12
ER -