Population-based analysis on the effect of nodal and distant metastases in sinonasal adenocarcinoma

Cynthia M. Chweya; Christopher M. Low; Jamie J. Van Gompel; Kathryn M. Van Abel; Janalee K. Stokken; Garret Choby

doi:10.1002/hed.26457

Population-based analysis on the effect of nodal and distant metastases in sinonasal adenocarcinoma

Cynthia M. Chweya, Christopher M. Low, Jamie J. Van Gompel, Kathryn M. Van Abel, Janalee K. Stokken, Garret Choby

Neurosurgery

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: Minimal information has been reported on the effect of distant and nodal metastases at the time of diagnosis on survival in patients with sinonasal adenocarcinoma (SNAC). Methods: The Surveillance, Epidemiology, and End Results database was utilized to compare overall survival (OS) and disease-specific survival (DSS). Results: Of the 325 patients with SNAC identified, 5-year and 10-year OS for all included patients was 64% and 58%, respectively. On multivariate analysis, the presence of distant metastases (P <.0001), maxillary and frontal sinus primary tumors (P =.0042, P =.0006), and increasing age (P =.007) were risk factors for worsened DSS. The presence of regional spread to multiple cervical nodal basins (OS RR 3.26, P =.002; DSS RR 2.51, P =.013) and a single nodal basin (DSS RR 2.19, P =.046) was associated with worsened survival compared to no regional spread. Conclusion: Survival in SNAC was significantly worsened with increasing age, tumor site of origin, and distant metastatic disease.

Original language	English (US)
Pages (from-to)	128-136
Number of pages	9
Journal	Head and Neck
Volume	43
Issue number	1
DOIs	https://doi.org/10.1002/hed.26457
State	Published - Jan 2021

Keywords

SEER database
distant metastases
epidemiology
nasal cavity
nodal metastases
paranasal sinuses
sinonasal adenocarcinoma
sinonasal malignancy

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.26457

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@article{17283e41abdb41968dbcdbc6b07b3bd1,

title = "Population-based analysis on the effect of nodal and distant metastases in sinonasal adenocarcinoma",

abstract = "Background: Minimal information has been reported on the effect of distant and nodal metastases at the time of diagnosis on survival in patients with sinonasal adenocarcinoma (SNAC). Methods: The Surveillance, Epidemiology, and End Results database was utilized to compare overall survival (OS) and disease-specific survival (DSS). Results: Of the 325 patients with SNAC identified, 5-year and 10-year OS for all included patients was 64% and 58%, respectively. On multivariate analysis, the presence of distant metastases (P <.0001), maxillary and frontal sinus primary tumors (P =.0042, P =.0006), and increasing age (P =.007) were risk factors for worsened DSS. The presence of regional spread to multiple cervical nodal basins (OS RR 3.26, P =.002; DSS RR 2.51, P =.013) and a single nodal basin (DSS RR 2.19, P =.046) was associated with worsened survival compared to no regional spread. Conclusion: Survival in SNAC was significantly worsened with increasing age, tumor site of origin, and distant metastatic disease.",

keywords = "SEER database, distant metastases, epidemiology, nasal cavity, nodal metastases, paranasal sinuses, sinonasal adenocarcinoma, sinonasal malignancy",

author = "Chweya, {Cynthia M.} and Low, {Christopher M.} and {Van Gompel}, {Jamie J.} and {Van Abel}, {Kathryn M.} and Stokken, {Janalee K.} and Garret Choby",

note = "Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC",

year = "2021",

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doi = "10.1002/hed.26457",

language = "English (US)",

volume = "43",

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T1 - Population-based analysis on the effect of nodal and distant metastases in sinonasal adenocarcinoma

AU - Chweya, Cynthia M.

AU - Low, Christopher M.

AU - Van Gompel, Jamie J.

AU - Van Abel, Kathryn M.

AU - Stokken, Janalee K.

AU - Choby, Garret

PY - 2021/1

Y1 - 2021/1

N2 - Background: Minimal information has been reported on the effect of distant and nodal metastases at the time of diagnosis on survival in patients with sinonasal adenocarcinoma (SNAC). Methods: The Surveillance, Epidemiology, and End Results database was utilized to compare overall survival (OS) and disease-specific survival (DSS). Results: Of the 325 patients with SNAC identified, 5-year and 10-year OS for all included patients was 64% and 58%, respectively. On multivariate analysis, the presence of distant metastases (P <.0001), maxillary and frontal sinus primary tumors (P =.0042, P =.0006), and increasing age (P =.007) were risk factors for worsened DSS. The presence of regional spread to multiple cervical nodal basins (OS RR 3.26, P =.002; DSS RR 2.51, P =.013) and a single nodal basin (DSS RR 2.19, P =.046) was associated with worsened survival compared to no regional spread. Conclusion: Survival in SNAC was significantly worsened with increasing age, tumor site of origin, and distant metastatic disease.

AB - Background: Minimal information has been reported on the effect of distant and nodal metastases at the time of diagnosis on survival in patients with sinonasal adenocarcinoma (SNAC). Methods: The Surveillance, Epidemiology, and End Results database was utilized to compare overall survival (OS) and disease-specific survival (DSS). Results: Of the 325 patients with SNAC identified, 5-year and 10-year OS for all included patients was 64% and 58%, respectively. On multivariate analysis, the presence of distant metastases (P <.0001), maxillary and frontal sinus primary tumors (P =.0042, P =.0006), and increasing age (P =.007) were risk factors for worsened DSS. The presence of regional spread to multiple cervical nodal basins (OS RR 3.26, P =.002; DSS RR 2.51, P =.013) and a single nodal basin (DSS RR 2.19, P =.046) was associated with worsened survival compared to no regional spread. Conclusion: Survival in SNAC was significantly worsened with increasing age, tumor site of origin, and distant metastatic disease.

KW - SEER database

KW - distant metastases

KW - epidemiology

KW - nasal cavity

KW - nodal metastases

KW - paranasal sinuses

KW - sinonasal adenocarcinoma

KW - sinonasal malignancy

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Population-based analysis on the effect of nodal and distant metastases in sinonasal adenocarcinoma

Abstract

Keywords

ASJC Scopus subject areas

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