TY - JOUR
T1 - Poorly differentiated carcinoma of the thyroid
T2 - Validation of the Turin proposal and analysis of IMP3 expression
AU - Asioli, Sofia
AU - Erickson, Lori A.
AU - Righi, Alberto
AU - Jin, Long
AU - Volante, Marco
AU - Jenkins, Sarah
AU - Papotti, Mauro
AU - Bussolati, Gianni
AU - Lloyd, Ricardo V.
N1 - Funding Information:
Sources of support: This work was supported by grants from the Italian Ministry of University (ex-60%), Ricerca Sanitaria Finalizzata Piedmont Region, World Wide Style Projects, Fondazione CRT, University of Turin (to SA). A Righi is part of and funded by the PhD programme ‘Scienze Biomediche ed Oncologia Umana: Tecniche avanzate di localizzazione dei tumori umani’, University of Turin.
PY - 2010/9
Y1 - 2010/9
N2 - The Turin Proposal algorithm defines poorly differentiated carcinoma on the basis of the presence of solid/trabecular/insular growth pattern, absence of conventional nuclear features of papillary carcinoma, and the presence of at least one of the following features: convoluted nuclei, mitotic activity 3/10 HPF, or tumor necrosis. IMP3 appears to have diagnostic and prognostic value in many solid tumors, including thyroid carcinomas. We examined a series of follicular-cell carcinomas with prominent solid patterns diagnosed at Mayo Clinic (56 cases) (Rochester, MN, USA) and at the University of Turin (96 cases) (Northern Italy) to validate the Turin consensus criteria defining poorly differentiated carcinoma of the thyroid and to evaluate the prevalence and prognostic behavior of this tumor. On this series, we analyzed the expression of conventional markers by immunohistochemistry and we investigated the expression of IMP3 by both immunohistochemistry and qRT-PCR. The prevalence of poorly differentiated carcinoma among the USA cases was 1.8% (56/3128) and that in the cases of Northern Italy was 6.7% (96/1442). Tumor characteristics were similar in the cases from the USA and from Italy except for extensive vascular invasion and a prevalent insular growth pattern (lower the former, higher the latter in the Italian series). In univariate analysis, the risk of death was higher for age 45, tumors 4 cm, and IMP3 positivity. Multivariate analysis showed that the risk of death from poorly differentiated carcinoma was higher for age 45. The Turin consensus criteria can reliably select poorly differentiated carcinomas. Tumors from the USA and from Italy showed similar overall survival, although the prevalence of poorly differentiated carcinoma was higher in Northern Italy. Expression of IMP3 appears to be an adverse prognostic factor for poorly differentiated thyroid carcinoma.
AB - The Turin Proposal algorithm defines poorly differentiated carcinoma on the basis of the presence of solid/trabecular/insular growth pattern, absence of conventional nuclear features of papillary carcinoma, and the presence of at least one of the following features: convoluted nuclei, mitotic activity 3/10 HPF, or tumor necrosis. IMP3 appears to have diagnostic and prognostic value in many solid tumors, including thyroid carcinomas. We examined a series of follicular-cell carcinomas with prominent solid patterns diagnosed at Mayo Clinic (56 cases) (Rochester, MN, USA) and at the University of Turin (96 cases) (Northern Italy) to validate the Turin consensus criteria defining poorly differentiated carcinoma of the thyroid and to evaluate the prevalence and prognostic behavior of this tumor. On this series, we analyzed the expression of conventional markers by immunohistochemistry and we investigated the expression of IMP3 by both immunohistochemistry and qRT-PCR. The prevalence of poorly differentiated carcinoma among the USA cases was 1.8% (56/3128) and that in the cases of Northern Italy was 6.7% (96/1442). Tumor characteristics were similar in the cases from the USA and from Italy except for extensive vascular invasion and a prevalent insular growth pattern (lower the former, higher the latter in the Italian series). In univariate analysis, the risk of death was higher for age 45, tumors 4 cm, and IMP3 positivity. Multivariate analysis showed that the risk of death from poorly differentiated carcinoma was higher for age 45. The Turin consensus criteria can reliably select poorly differentiated carcinomas. Tumors from the USA and from Italy showed similar overall survival, although the prevalence of poorly differentiated carcinoma was higher in Northern Italy. Expression of IMP3 appears to be an adverse prognostic factor for poorly differentiated thyroid carcinoma.
UR - http://www.scopus.com/inward/record.url?scp=77956294580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956294580&partnerID=8YFLogxK
U2 - 10.1038/modpathol.2010.117
DO - 10.1038/modpathol.2010.117
M3 - Article
C2 - 20562850
AN - SCOPUS:77956294580
SN - 0893-3952
VL - 23
SP - 1269
EP - 1278
JO - Modern Pathology
JF - Modern Pathology
IS - 9
ER -