Poor tolerance to high doses of thalidomide in patients with primary systemic amyloidosis

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Abstract

Treatments effective against multiple myeloma may be useful in primary systemic amyloidosis (AL). Thalidomide is active in myeloma. Results of the first 12 patients enrolled on aphase II trial of thalidomide for AL are presented. Progressive edema, cognitive difficulties, and constipation occurred in approximately 75%; dyspnea, dizziness and rash in 50%. Five developed progressive renal insufficiency. Deep venous thrombosis and syncope each occurred in two. Median time on the study was 72 days, range was 25 to 333 days. All 12 have withdrawn from the study (side-effects, 6; progression, 4; and death, 2 patients). AL patients do not tolerate high dose thalidomide.

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalAmyloid
Volume10
Issue number4
DOIs
StatePublished - Dec 2003

Keywords

  • Amyloidosis
  • Multiple myeloma
  • Thalidomide
  • Toxicity

ASJC Scopus subject areas

  • Internal Medicine

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