Poly(propylene fumarate) bone tissue engineering scaffold fabrication using stereolithography: Effects of resin formulations and laser parameters

Kee Won Lee, Shanfeng Wang, Bradley C. Fox, Erik L. Ritman, Michael J Yaszemski, Lichun Lu

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Stereolithography using photo-cross-linkable polymeric biomaterials is an effective technique for fabricating highly complex three-dimensional (3D) scaffolds with controlled microstructures for tissue engineering applications. In this study, we have optimized the UV curable polymer solution composition and laser parameters for the stereolithography machine. Poly(propylene fumarate) (PPF) was used as the biomaterial, diethyl fumarate (DEF) was used as the solvent, and bisacrylphosphrine oxide (BAPO) was used as the photoinitiator. Three different weight ratios of PPF/DEF and BAPO contents were characterized by measuring the viscosities and thermal properties of the un-cross-linked solutions and the mechanical properties of the formed scaffolds. After optimizing the resin composition by satisfying both the viscosity limitation and the mechanical requirement, laser parameters such as critical exposure (E c) and penetration depth (D p) were determined from the working curve and the relationship between laser speed and energy by measuring the thickness of predesigned windows fabricated in stereolithography with different ranges of E c and D p. Three-dimensional scaffolds with various pore sizes, pore shapes, and porosities were designed in computer-aided design (CAD) software and were fabricated in stereolithography. The fabricated scaffolds were characterized by measuring external dimensions, porosities, mean pore sizes, and compressive moduli and were compared to the CAD models. Feature accuracy in the xy-plane was achieved and overcuring of the resin in z-axis was minimized. The stereolithographically fabricated scaffolds with controlled microstructures can be useful in diverse tissue engineering applications.

Original languageEnglish (US)
Pages (from-to)1077-1084
Number of pages8
JournalBiomacromolecules
Volume8
Issue number4
DOIs
StatePublished - Apr 2007

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Tissue Scaffolds
Stereolithography
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Scaffolds
Computer-Aided Design
Polypropylenes
Bone
Lasers
Resins
Porosity
Biocompatible Materials
Bone and Bones
Fabrication
Viscosity
Oxides
Biomaterials
Pore size
Computer aided design

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Poly(propylene fumarate) bone tissue engineering scaffold fabrication using stereolithography : Effects of resin formulations and laser parameters. / Lee, Kee Won; Wang, Shanfeng; Fox, Bradley C.; Ritman, Erik L.; Yaszemski, Michael J; Lu, Lichun.

In: Biomacromolecules, Vol. 8, No. 4, 04.2007, p. 1077-1084.

Research output: Contribution to journalArticle

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