We investigated two patients with the idiopathic hyper-eosinophilic syndrome and peripheral neuropathy. Clinical, EMG, and pathological findings were consistent with axonal polyneuropathy. Morphologic changes of the nerve biopsies suggested axonal damage secondary to increased endoneurial pressure from leakage of capillaries. We postulate that endothelial cell damage, followed by nerve edema, is the first step in the pathogenesis of peripheral neuropathy in these patients.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Mar 1988|
ASJC Scopus subject areas
- Clinical Neurology