Polymyositis and Dermatomyositis

Reinhard Hohlfeld, Andrew G Engel

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter discusses polymyositis (PM) and dermatomyositis (DM), which are often categorized as "dysimmune myopathies" or "idiopathic inflammatory myopathies." It is presently thought that PM is a T-cell mediated, presumably autoimmune disorder, whereas DM is an antibody-mediated vascular disorder. In both PM and DM, proximal muscles are usually symmetrically affected. Respiratory, pharyngeal and neck muscles may be involved during later stages. The history, clinical symptoms and signs, elevated serum levels of muscle enzymes, electrophysiological changes, and histologic findings together provide the basis for the diagnosis. The main diagnostic criteria and features of the different inflammatory myopathies are compared and summarized in this chapter. Some characteristic histologic features of DM and PM are also described. Furthermore, different effector mechanisms have been attributed to PM, which is mainly T-cell- mediated and DM, which mainly is antibody-mediated, and a unique ?? T-cell-mediated subtype of PM has been described. Challenges for future research include the identification of the elusive antigens and the triggering mechanisms of the immune reactions against muscle fibers.

Original languageEnglish (US)
Title of host publicationThe Autoimmune Diseases
PublisherElsevier Inc.
Pages453-463
Number of pages11
ISBN (Print)9780125959612
DOIs
StatePublished - 2006

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Dermatomyositis
Polymyositis
Myositis
T-Lymphocytes
Muscles
Pharyngeal Muscles
Neck Muscles
Respiratory Muscles
Antibodies
Muscular Diseases
Signs and Symptoms
Blood Vessels
History
Antigens
Enzymes
Serum

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Hohlfeld, R., & Engel, A. G. (2006). Polymyositis and Dermatomyositis. In The Autoimmune Diseases (pp. 453-463). Elsevier Inc.. https://doi.org/10.1016/B978-012595961-2/50037-8

Polymyositis and Dermatomyositis. / Hohlfeld, Reinhard; Engel, Andrew G.

The Autoimmune Diseases. Elsevier Inc., 2006. p. 453-463.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hohlfeld, R & Engel, AG 2006, Polymyositis and Dermatomyositis. in The Autoimmune Diseases. Elsevier Inc., pp. 453-463. https://doi.org/10.1016/B978-012595961-2/50037-8
Hohlfeld R, Engel AG. Polymyositis and Dermatomyositis. In The Autoimmune Diseases. Elsevier Inc. 2006. p. 453-463 https://doi.org/10.1016/B978-012595961-2/50037-8
Hohlfeld, Reinhard ; Engel, Andrew G. / Polymyositis and Dermatomyositis. The Autoimmune Diseases. Elsevier Inc., 2006. pp. 453-463
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