Polymyositis

Reinhard Hohlfeld, Andrew G. Engel, Marinos C. Dalakas

Research output: Contribution to journalLetterpeer-review

3 Scopus citations

Abstract

To the Editor: In his excellent review (Nov. 21 issue),1 Dr. Dalakas referred to a case of polymyositis that we described2 as one that was “mediated by T cells expressing the γ/δ receptor, which have cytotoxic activity restricted to the MHC-I [major-histocompatibility-complex class I] antigen.” We wish to emphasize that the mere colocalization of MHC-I antigen and γ/δ T cells does not necessarily imply that the antigen functions as the restrictive element of γ/δ T cells. Although the existence of γ/δ T cells recognizing MHC-I antigen has been formally demonstrated,3 the majority of such cells apparently recognize antigens either independently.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume326
Issue number19
DOIs
StatePublished - May 7 1992

ASJC Scopus subject areas

  • Medicine(all)

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