Polymorphous hemangioendothelioma: A report of two cases, one affecting extranodal soft tissues, and review of the literature

Antonio G. Nascimento, Gary Keeney, Raf Sciot, Christopher D M Fletcher

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Polymorphous hemangioendothelioma (PH) is a rare vascular neoplasm occurring in lymph nodes. It has been considered a borderline malignant tumor, mainly because of a local recurrence in one of the three cases described to date. This report adds two additional cases, one in which the tumor was extranodal. An extensive immunohistochemical study and thorough literature review were undertaken. The patients, a 55-year-old man and a 28- year-old man, both asymptomatic, presented with tumors involving a left pulmonary hilar lymph node (3 cm) and the soft tissues of the left paravertebral region (4 cm), respectively. The tumors were composed of an admixture of solid, primitive vascular and ectatic angiomatous components, with both elements formed by uniform, polygonal cells. In one case, the cells marked for CD31 and factor VIII, and the other case was positive for CD34. Neither case marked for epithelial membrane antigen and keratin. One tumor partially replaced a lymph node, and no nodal tissue was identified in the other. Of the three previously reported cases of nodal PH, one had recurring and metastatic behavior. PH is a rare, malignant vascular neoplasm that most frequently involves lymph nodes, but it can also affect extranodal locations.

Original languageEnglish (US)
Pages (from-to)1083-1089
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume21
Issue number9
DOIs
StatePublished - 1997

Fingerprint

Hemangioendothelioma
Lymph Nodes
Vascular Neoplasms
Neoplasms
Mucin-1
Factor VIII
Keratins
Blood Vessels
Recurrence
Lung

Keywords

  • Extranodal neoplasm
  • Hemangioendothelioma
  • Lymph nodes
  • Polymorphous
  • Vascular neoplasm

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Polymorphous hemangioendothelioma : A report of two cases, one affecting extranodal soft tissues, and review of the literature. / Nascimento, Antonio G.; Keeney, Gary; Sciot, Raf; Fletcher, Christopher D M.

In: American Journal of Surgical Pathology, Vol. 21, No. 9, 1997, p. 1083-1089.

Research output: Contribution to journalArticle

@article{29874f0d61084b3e9ef6312d9dfcda58,
title = "Polymorphous hemangioendothelioma: A report of two cases, one affecting extranodal soft tissues, and review of the literature",
abstract = "Polymorphous hemangioendothelioma (PH) is a rare vascular neoplasm occurring in lymph nodes. It has been considered a borderline malignant tumor, mainly because of a local recurrence in one of the three cases described to date. This report adds two additional cases, one in which the tumor was extranodal. An extensive immunohistochemical study and thorough literature review were undertaken. The patients, a 55-year-old man and a 28- year-old man, both asymptomatic, presented with tumors involving a left pulmonary hilar lymph node (3 cm) and the soft tissues of the left paravertebral region (4 cm), respectively. The tumors were composed of an admixture of solid, primitive vascular and ectatic angiomatous components, with both elements formed by uniform, polygonal cells. In one case, the cells marked for CD31 and factor VIII, and the other case was positive for CD34. Neither case marked for epithelial membrane antigen and keratin. One tumor partially replaced a lymph node, and no nodal tissue was identified in the other. Of the three previously reported cases of nodal PH, one had recurring and metastatic behavior. PH is a rare, malignant vascular neoplasm that most frequently involves lymph nodes, but it can also affect extranodal locations.",
keywords = "Extranodal neoplasm, Hemangioendothelioma, Lymph nodes, Polymorphous, Vascular neoplasm",
author = "Nascimento, {Antonio G.} and Gary Keeney and Raf Sciot and Fletcher, {Christopher D M}",
year = "1997",
doi = "10.1097/00000478-199709000-00013",
language = "English (US)",
volume = "21",
pages = "1083--1089",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Polymorphous hemangioendothelioma

T2 - A report of two cases, one affecting extranodal soft tissues, and review of the literature

AU - Nascimento, Antonio G.

AU - Keeney, Gary

AU - Sciot, Raf

AU - Fletcher, Christopher D M

PY - 1997

Y1 - 1997

N2 - Polymorphous hemangioendothelioma (PH) is a rare vascular neoplasm occurring in lymph nodes. It has been considered a borderline malignant tumor, mainly because of a local recurrence in one of the three cases described to date. This report adds two additional cases, one in which the tumor was extranodal. An extensive immunohistochemical study and thorough literature review were undertaken. The patients, a 55-year-old man and a 28- year-old man, both asymptomatic, presented with tumors involving a left pulmonary hilar lymph node (3 cm) and the soft tissues of the left paravertebral region (4 cm), respectively. The tumors were composed of an admixture of solid, primitive vascular and ectatic angiomatous components, with both elements formed by uniform, polygonal cells. In one case, the cells marked for CD31 and factor VIII, and the other case was positive for CD34. Neither case marked for epithelial membrane antigen and keratin. One tumor partially replaced a lymph node, and no nodal tissue was identified in the other. Of the three previously reported cases of nodal PH, one had recurring and metastatic behavior. PH is a rare, malignant vascular neoplasm that most frequently involves lymph nodes, but it can also affect extranodal locations.

AB - Polymorphous hemangioendothelioma (PH) is a rare vascular neoplasm occurring in lymph nodes. It has been considered a borderline malignant tumor, mainly because of a local recurrence in one of the three cases described to date. This report adds two additional cases, one in which the tumor was extranodal. An extensive immunohistochemical study and thorough literature review were undertaken. The patients, a 55-year-old man and a 28- year-old man, both asymptomatic, presented with tumors involving a left pulmonary hilar lymph node (3 cm) and the soft tissues of the left paravertebral region (4 cm), respectively. The tumors were composed of an admixture of solid, primitive vascular and ectatic angiomatous components, with both elements formed by uniform, polygonal cells. In one case, the cells marked for CD31 and factor VIII, and the other case was positive for CD34. Neither case marked for epithelial membrane antigen and keratin. One tumor partially replaced a lymph node, and no nodal tissue was identified in the other. Of the three previously reported cases of nodal PH, one had recurring and metastatic behavior. PH is a rare, malignant vascular neoplasm that most frequently involves lymph nodes, but it can also affect extranodal locations.

KW - Extranodal neoplasm

KW - Hemangioendothelioma

KW - Lymph nodes

KW - Polymorphous

KW - Vascular neoplasm

UR - http://www.scopus.com/inward/record.url?scp=0030985431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030985431&partnerID=8YFLogxK

U2 - 10.1097/00000478-199709000-00013

DO - 10.1097/00000478-199709000-00013

M3 - Article

C2 - 9298885

AN - SCOPUS:0030985431

VL - 21

SP - 1083

EP - 1089

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 9

ER -