Polymorphisms of the TAP2 gene may influence antibody response to live measles vaccine virus

Mary S. Hayney; Gregory A. Poland; Patricia Dimanlig; Daniel J. Schaid; Robert M. Jacobson; James J. Lipsky

doi:10.1016/S0264-410X(96)00133-8

Polymorphisms of the TAP2 gene may influence antibody response to live measles vaccine virus

Mary S. Hayney, Gregory A. Poland, Patricia Dimanlig, Daniel J. Schaid, Robert M. Jacobson, James J. Lipsky

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The transporter associated with antigen processing (TAP) gene products transport peptides from the cytosol to the endoplasmic reticulum for processing by the immune system. We hypothesized that polymorphisms within the TAP genes may influence measles vaccine antigen processing and hence antibody response. TAP genotypes were determined for subjects who were measles vaccine nonresponders (n = 32) and hyper-responders (n = 28). TAP1 and TAP2 alleles were determined by PCR amplification of specific alleles (PASA). Measles vaccine nonresponders were more likely to be homozygous at TAP2 position 665 than were hyper-responders (OR = 5.0, P = 0.016). Lastly, a trend was found in the overall distribution of all TAP2 genotype frequencies between hyper-responders and nonresponders (P = 0.08). No association was found between TAP1 polymorphisms and vaccine response. These data reveal an association between TAP2 genotype and measles vaccine antibody response which may explain one mechanism behind vaccine failure.

Original language	English (US)
Pages (from-to)	3-6
Number of pages	4
Journal	Vaccine
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/S0264-410X(96)00133-8
State	Published - Jan 1997

Keywords

TAP gene
measles vaccine

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(96)00133-8

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title = "Polymorphisms of the TAP2 gene may influence antibody response to live measles vaccine virus",

abstract = "The transporter associated with antigen processing (TAP) gene products transport peptides from the cytosol to the endoplasmic reticulum for processing by the immune system. We hypothesized that polymorphisms within the TAP genes may influence measles vaccine antigen processing and hence antibody response. TAP genotypes were determined for subjects who were measles vaccine nonresponders (n = 32) and hyper-responders (n = 28). TAP1 and TAP2 alleles were determined by PCR amplification of specific alleles (PASA). Measles vaccine nonresponders were more likely to be homozygous at TAP2 position 665 than were hyper-responders (OR = 5.0, P = 0.016). Lastly, a trend was found in the overall distribution of all TAP2 genotype frequencies between hyper-responders and nonresponders (P = 0.08). No association was found between TAP1 polymorphisms and vaccine response. These data reveal an association between TAP2 genotype and measles vaccine antibody response which may explain one mechanism behind vaccine failure.",

keywords = "TAP gene, measles vaccine",

author = "Hayney, {Mary S.} and Poland, {Gregory A.} and Patricia Dimanlig and Schaid, {Daniel J.} and Jacobson, {Robert M.} and Lipsky, {James J.}",

note = "Funding Information: This research was supported in part by Grants HHS FD-T-000-886-03 and NIH ROl-AI-33144 and in part, with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Contract No. NOl-AI-45240, Dr Poland is a Mayo Rappaport Scholar. Portions of this research were presented at Molecular Approaches to the Control of Infectious Diseases-Cold Spring Harbor Laboratory, New York, and 7th European Congress on Clinical Microbiology and Infectious Diseases-Vienna, Austria. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.",

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AU - Jacobson, Robert M.

AU - Lipsky, James J.

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N2 - The transporter associated with antigen processing (TAP) gene products transport peptides from the cytosol to the endoplasmic reticulum for processing by the immune system. We hypothesized that polymorphisms within the TAP genes may influence measles vaccine antigen processing and hence antibody response. TAP genotypes were determined for subjects who were measles vaccine nonresponders (n = 32) and hyper-responders (n = 28). TAP1 and TAP2 alleles were determined by PCR amplification of specific alleles (PASA). Measles vaccine nonresponders were more likely to be homozygous at TAP2 position 665 than were hyper-responders (OR = 5.0, P = 0.016). Lastly, a trend was found in the overall distribution of all TAP2 genotype frequencies between hyper-responders and nonresponders (P = 0.08). No association was found between TAP1 polymorphisms and vaccine response. These data reveal an association between TAP2 genotype and measles vaccine antibody response which may explain one mechanism behind vaccine failure.

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Polymorphisms of the TAP2 gene may influence antibody response to live measles vaccine virus

Abstract

Keywords

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