Polymorphisms in the wilms tumor gene are associated with interindividual variations in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination

Emily A. Voigt, Iana H. Haralambieva, Beth L. Larrabee, Richard B Kennedy, Inna G. Ovsyannikova, Daniel J Schaid, Gregory A. Poland

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus-specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 x 10-8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects' peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination.

Original languageEnglish (US)
Pages (from-to)560-566
Number of pages7
JournalJournal of Infectious Diseases
Volume217
Issue number4
DOIs
StatePublished - Feb 15 2018

Fingerprint

Wilms' Tumor Genes
Rubella virus
Mumps
Rubella
Measles
Cellular Immunity
Vaccination
Single Nucleotide Polymorphism
Genetic Polymorphisms
Immunity
Genome-Wide Association Study
Humoral Immunity
Interferons
Interleukin-6
Blood Cells
Vaccines
Infection
Genes

Keywords

  • Genetic
  • Genome-wide association study
  • IL-6
  • Immunity
  • Measles-mumps-rubella vaccine
  • Polymorphisms
  • Rubella
  • Rubella virus
  • SNP

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Polymorphisms in the wilms tumor gene are associated with interindividual variations in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination. / Voigt, Emily A.; Haralambieva, Iana H.; Larrabee, Beth L.; Kennedy, Richard B; Ovsyannikova, Inna G.; Schaid, Daniel J; Poland, Gregory A.

In: Journal of Infectious Diseases, Vol. 217, No. 4, 15.02.2018, p. 560-566.

Research output: Contribution to journalArticle

@article{94667d94bf514d058303a1f345cef710,
title = "Polymorphisms in the wilms tumor gene are associated with interindividual variations in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination",
abstract = "Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5{\%} of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus-specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 x 10-8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects' peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination.",
keywords = "Genetic, Genome-wide association study, IL-6, Immunity, Measles-mumps-rubella vaccine, Polymorphisms, Rubella, Rubella virus, SNP",
author = "Voigt, {Emily A.} and Haralambieva, {Iana H.} and Larrabee, {Beth L.} and Kennedy, {Richard B} and Ovsyannikova, {Inna G.} and Schaid, {Daniel J} and Poland, {Gregory A.}",
year = "2018",
month = "2",
day = "15",
doi = "10.1093/infdis/jix538",
language = "English (US)",
volume = "217",
pages = "560--566",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Polymorphisms in the wilms tumor gene are associated with interindividual variations in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination

AU - Voigt, Emily A.

AU - Haralambieva, Iana H.

AU - Larrabee, Beth L.

AU - Kennedy, Richard B

AU - Ovsyannikova, Inna G.

AU - Schaid, Daniel J

AU - Poland, Gregory A.

PY - 2018/2/15

Y1 - 2018/2/15

N2 - Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus-specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 x 10-8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects' peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination.

AB - Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus-specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 x 10-8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects' peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination.

KW - Genetic

KW - Genome-wide association study

KW - IL-6

KW - Immunity

KW - Measles-mumps-rubella vaccine

KW - Polymorphisms

KW - Rubella

KW - Rubella virus

KW - SNP

UR - http://www.scopus.com/inward/record.url?scp=85044468860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044468860&partnerID=8YFLogxK

U2 - 10.1093/infdis/jix538

DO - 10.1093/infdis/jix538

M3 - Article

VL - 217

SP - 560

EP - 566

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 4

ER -