Polymorphisms in the wilms tumor gene are associated with interindividual variations in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination

Emily A. Voigt, Iana H. Haralambieva, Beth L. Larrabee, Richard B Kennedy, Inna G. Ovsyannikova, Daniel J Schaid, Gregory A. Poland

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus-specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 x 10-8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects' peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination.

Original languageEnglish (US)
Pages (from-to)560-566
Number of pages7
JournalJournal of Infectious Diseases
Volume217
Issue number4
DOIs
StatePublished - Feb 15 2018

Keywords

  • Genetic
  • Genome-wide association study
  • IL-6
  • Immunity
  • Measles-mumps-rubella vaccine
  • Polymorphisms
  • Rubella
  • Rubella virus
  • SNP

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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