Abstract
Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus-specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 x 10-8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects' peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 560-566 |
| Number of pages | 7 |
| Journal | Journal of Infectious Diseases |
| Volume | 217 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 15 2018 |
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Keywords
- Genetic
- Genome-wide association study
- IL-6
- Immunity
- Measles-mumps-rubella vaccine
- Polymorphisms
- Rubella
- Rubella virus
- SNP
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
Cite this
Polymorphisms in the wilms tumor gene are associated with interindividual variations in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination. / Voigt, Emily A.; Haralambieva, Iana H.; Larrabee, Beth L.; Kennedy, Richard B; Ovsyannikova, Inna G.; Schaid, Daniel J; Poland, Gregory A.
In: Journal of Infectious Diseases, Vol. 217, No. 4, 15.02.2018, p. 560-566.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polymorphisms in the wilms tumor gene are associated with interindividual variations in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination
AU - Voigt, Emily A.
AU - Haralambieva, Iana H.
AU - Larrabee, Beth L.
AU - Kennedy, Richard B
AU - Ovsyannikova, Inna G.
AU - Schaid, Daniel J
AU - Poland, Gregory A.
PY - 2018/2/15
Y1 - 2018/2/15
N2 - Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus-specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 x 10-8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects' peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination.
AB - Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-term protective immunity. To expand upon our previous work identifying genetic polymorphisms that are associated with these interindividual differences in humoral immunity to rubella virus, we performed a genome-wide association study in a large cohort of 1843 subjects to discover single-nucleotide polymorphisms (SNPs) associated with rubella virus-specific cellular immune responses. We identified SNPs in the Wilms tumor protein gene (WT1) that were significantly associated (P < 5 x 10-8) with interindividual variations in rubella-specific interleukin 6 secretion from subjects' peripheral blood mononuclear cells postvaccination. No SNPs were found to be significantly associated with variations in rubella-specific interferon-γ secretion. Our findings demonstrate that genetic polymorphisms in the WT1 gene in subjects of European ancestry are associated with interindividual differences in rubella virus-specific cellular immunity after measles-mumps-rubella II vaccination.
KW - Genetic
KW - Genome-wide association study
KW - IL-6
KW - Immunity
KW - Measles-mumps-rubella vaccine
KW - Polymorphisms
KW - Rubella
KW - Rubella virus
KW - SNP
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UR - http://www.scopus.com/inward/citedby.url?scp=85044468860&partnerID=8YFLogxK
U2 - 10.1093/infdis/jix538
DO - 10.1093/infdis/jix538
M3 - Article
VL - 217
SP - 560
EP - 566
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 4
ER -