TY - JOUR
T1 - Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination
AU - Ovsyannikova, Inna G.
AU - Haralambieva, Lana H.
AU - Dhimán, Nestam
AU - O'Byrne, Megan M.
AU - Pankratz, V. Shane
AU - Jacobson, Robert M.
AU - Poland, Gregory A.
N1 - Funding Information:
Financial support: National Institutes of Health (NIH) grants AI 48793 and AI 33144. The contents of this article are solely the responsibility of the authors and do not necessarily represent the official view of NIH.
PY - 2010/1/15
Y1 - 2010/1/15
N2 - Background. Genetic polymorphisms play an important role in rubella vaccine-induced immunity. Methods. We genotyped 714 healthy children after 2 age-appropriate doses of rubella-containing vaccine for 142 potential single-nucleotide polymorphisms (SNPs). Results. Specific polymorphisms in the vitamin A receptor, retinoic acid-inducible gene I (RIG-I), and tripartite motif 5 and 22 (TRIM5 and TRIM22) genes were significantly associated with rubella vaccine humoral immunity. The minor allele of the rs4416353 in the vitamin A receptor gene was associated with an allele dose-related decrease (P = .019) in rubella antibody response. The minor allele of rs6793694, in the vitamin A receptor gene, was associated with an allele dose-related antibody decrease (P = .039). The minor variant of nonsynonymous SNP rsl0813831 (Arg7Cys) in the RIG-I gene was associated with an allele dose-related decrease in rubella antibody level from 37.4 to 28.0 IU/mL (P = .035), whereas increased representation of the minor allele of the 5UTR SNP (rs3824949, P = .015) in the antiretroviral TRIM5 gene was associated with an allele dose-related increase in rubella antibody. It is of particular interest that the nonsynonymous SNP rs3740996 (His43Tyr) in the TRIM5 gene was associated with variations in rubella antibody response (P = .016) after having been previously found to play a significant functional role. Conclusions. These findings further expand our immunogenetic understanding of mechanisms of rubella vaccine-induced immunity.
AB - Background. Genetic polymorphisms play an important role in rubella vaccine-induced immunity. Methods. We genotyped 714 healthy children after 2 age-appropriate doses of rubella-containing vaccine for 142 potential single-nucleotide polymorphisms (SNPs). Results. Specific polymorphisms in the vitamin A receptor, retinoic acid-inducible gene I (RIG-I), and tripartite motif 5 and 22 (TRIM5 and TRIM22) genes were significantly associated with rubella vaccine humoral immunity. The minor allele of the rs4416353 in the vitamin A receptor gene was associated with an allele dose-related decrease (P = .019) in rubella antibody response. The minor allele of rs6793694, in the vitamin A receptor gene, was associated with an allele dose-related antibody decrease (P = .039). The minor variant of nonsynonymous SNP rsl0813831 (Arg7Cys) in the RIG-I gene was associated with an allele dose-related decrease in rubella antibody level from 37.4 to 28.0 IU/mL (P = .035), whereas increased representation of the minor allele of the 5UTR SNP (rs3824949, P = .015) in the antiretroviral TRIM5 gene was associated with an allele dose-related increase in rubella antibody. It is of particular interest that the nonsynonymous SNP rs3740996 (His43Tyr) in the TRIM5 gene was associated with variations in rubella antibody response (P = .016) after having been previously found to play a significant functional role. Conclusions. These findings further expand our immunogenetic understanding of mechanisms of rubella vaccine-induced immunity.
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U2 - 10.1086/649588
DO - 10.1086/649588
M3 - Article
C2 - 20001730
AN - SCOPUS:75649144807
SN - 0022-1899
VL - 201
SP - 207
EP - 213
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -