Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia

Stanley Zammit; Gaynor Jones; Susan J. Jones; Nadine Norton; Robert D. Sanders; Charis Milham; Geraldine M. McCarthy; Lisa A. Jones; Alastair G. Cardno; Marion Gray; Kieran C. Murphy; Michael C. O'Donovan; Michael J. Owen

doi:10.1002/ajmg.b.30021

Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia

Stanley Zammit, Gaynor Jones, Susan J. Jones, Nadine Norton, Robert D. Sanders, Charis Milham, Geraldine M. McCarthy, Lisa A. Jones, Alastair G. Cardno, Marion Gray, Kieran C. Murphy, Michael C. O'Donovan, Michael J. Owen

Cancer Biology

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70 Scopus citations

Abstract

Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined he relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior.

Original language	English (US)
Pages (from-to)	19-20
Number of pages	2
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	128 B
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.b.30021
State	Published - Jul 1 2004

Keywords

Aggression
Association
Catecholamines
Epistasis
Functional

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1002/ajmg.b.30021

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Zammit, S., Jones, G., Jones, S. J., Norton, N., Sanders, R. D., Milham, C., McCarthy, G. M., Jones, L. A., Cardno, A. G., Gray, M., Murphy, K. C., O'Donovan, M. C., & Owen, M. J. (2004). Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics, 128 B(1), 19-20. https://doi.org/10.1002/ajmg.b.30021

Zammit, S, Jones, G, Jones, SJ, Norton, N, Sanders, RD, Milham, C, McCarthy, GM, Jones, LA, Cardno, AG, Gray, M, Murphy, KC, O'Donovan, MC & Owen, MJ 2004, 'Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 128 B, no. 1, pp. 19-20. https://doi.org/10.1002/ajmg.b.30021

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abstract = "Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined he relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior.",

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Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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