Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1)

Suzette J Bielinski, Alex P. Reiner, Deborah Nickerson, Chris Carlson, Kent R Bailey, Bharat Thyagarajan, Leslie A. Lange, Eric A. Boerwinkle, David R. Jacobs, Myron D. Gross

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: Polymorphisms within the ICAM1 structural gene have been shown to influence circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) but their relation to atherosclerosis has not been clearly established. We sought to determine whether ICAM1 SNPs are associated with circulating sICAM-1 concentration, coronary artery calcium (CAC), and common and internal carotid intima medial thickness (IMT). Methods and Results: 3550 black and white Coronary Artery Risk Development in Young Adults (CARDIA) Study subjects who participated in the year 15 and/or 20 examinations and were part of the Young Adult Longitudinal Study of Antioxidants (YALTA) ancillary study were included in this analysis. In whites, rs5498 was significantly associated with sICAM-1 (p< 0.001) and each G-allele of rs5498 was associated with 5% higher sICAM-1 concentration. In blacks, each C-allele of rs5490 was associated with 6% higher sICAM-1 level; this SNP was in strong linkage disequilibrium with rs5491, a functional variant. Subclinical measurements of atherosclerosis in either year 15 or year 20 were not significantly related to ICAM1 SNPs. Conclusions: In CARDIA, ICAM1 DNA segment variants were associated with sICAM-1 protein level including the novel finding that levels differ by the functional variant rs5491. However, ICAM1 SNPs were not strongly related to either IMT or CAC. Our findings in CARDIA suggest that ICAM1 variants are not major early contributors to subclinical atherosclerosis.

Original languageEnglish (US)
Pages (from-to)390-394
Number of pages5
JournalAtherosclerosis
Volume216
Issue number2
DOIs
StatePublished - Jun 2011

Fingerprint

Intercellular Adhesion Molecule-1
Coronary Vessels
Single Nucleotide Polymorphism
Young Adult
Genes
Atherosclerosis
Alleles
Calcium
Linkage Disequilibrium
Longitudinal Studies
Antioxidants
DNA
Proteins

Keywords

  • Atherosclerosis
  • Cell adhesion molecules
  • Coronary calcium
  • Genetics
  • Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1). / Bielinski, Suzette J; Reiner, Alex P.; Nickerson, Deborah; Carlson, Chris; Bailey, Kent R; Thyagarajan, Bharat; Lange, Leslie A.; Boerwinkle, Eric A.; Jacobs, David R.; Gross, Myron D.

In: Atherosclerosis, Vol. 216, No. 2, 06.2011, p. 390-394.

Research output: Contribution to journalArticle

Bielinski, SJ, Reiner, AP, Nickerson, D, Carlson, C, Bailey, KR, Thyagarajan, B, Lange, LA, Boerwinkle, EA, Jacobs, DR & Gross, MD 2011, 'Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1)', Atherosclerosis, vol. 216, no. 2, pp. 390-394. https://doi.org/10.1016/j.atherosclerosis.2011.02.018
Bielinski, Suzette J ; Reiner, Alex P. ; Nickerson, Deborah ; Carlson, Chris ; Bailey, Kent R ; Thyagarajan, Bharat ; Lange, Leslie A. ; Boerwinkle, Eric A. ; Jacobs, David R. ; Gross, Myron D. / Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1). In: Atherosclerosis. 2011 ; Vol. 216, No. 2. pp. 390-394.
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abstract = "Objective: Polymorphisms within the ICAM1 structural gene have been shown to influence circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) but their relation to atherosclerosis has not been clearly established. We sought to determine whether ICAM1 SNPs are associated with circulating sICAM-1 concentration, coronary artery calcium (CAC), and common and internal carotid intima medial thickness (IMT). Methods and Results: 3550 black and white Coronary Artery Risk Development in Young Adults (CARDIA) Study subjects who participated in the year 15 and/or 20 examinations and were part of the Young Adult Longitudinal Study of Antioxidants (YALTA) ancillary study were included in this analysis. In whites, rs5498 was significantly associated with sICAM-1 (p< 0.001) and each G-allele of rs5498 was associated with 5{\%} higher sICAM-1 concentration. In blacks, each C-allele of rs5490 was associated with 6{\%} higher sICAM-1 level; this SNP was in strong linkage disequilibrium with rs5491, a functional variant. Subclinical measurements of atherosclerosis in either year 15 or year 20 were not significantly related to ICAM1 SNPs. Conclusions: In CARDIA, ICAM1 DNA segment variants were associated with sICAM-1 protein level including the novel finding that levels differ by the functional variant rs5491. However, ICAM1 SNPs were not strongly related to either IMT or CAC. Our findings in CARDIA suggest that ICAM1 variants are not major early contributors to subclinical atherosclerosis.",
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AU - Reiner, Alex P.

AU - Nickerson, Deborah

AU - Carlson, Chris

AU - Bailey, Kent R

AU - Thyagarajan, Bharat

AU - Lange, Leslie A.

AU - Boerwinkle, Eric A.

AU - Jacobs, David R.

AU - Gross, Myron D.

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N2 - Objective: Polymorphisms within the ICAM1 structural gene have been shown to influence circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) but their relation to atherosclerosis has not been clearly established. We sought to determine whether ICAM1 SNPs are associated with circulating sICAM-1 concentration, coronary artery calcium (CAC), and common and internal carotid intima medial thickness (IMT). Methods and Results: 3550 black and white Coronary Artery Risk Development in Young Adults (CARDIA) Study subjects who participated in the year 15 and/or 20 examinations and were part of the Young Adult Longitudinal Study of Antioxidants (YALTA) ancillary study were included in this analysis. In whites, rs5498 was significantly associated with sICAM-1 (p< 0.001) and each G-allele of rs5498 was associated with 5% higher sICAM-1 concentration. In blacks, each C-allele of rs5490 was associated with 6% higher sICAM-1 level; this SNP was in strong linkage disequilibrium with rs5491, a functional variant. Subclinical measurements of atherosclerosis in either year 15 or year 20 were not significantly related to ICAM1 SNPs. Conclusions: In CARDIA, ICAM1 DNA segment variants were associated with sICAM-1 protein level including the novel finding that levels differ by the functional variant rs5491. However, ICAM1 SNPs were not strongly related to either IMT or CAC. Our findings in CARDIA suggest that ICAM1 variants are not major early contributors to subclinical atherosclerosis.

AB - Objective: Polymorphisms within the ICAM1 structural gene have been shown to influence circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) but their relation to atherosclerosis has not been clearly established. We sought to determine whether ICAM1 SNPs are associated with circulating sICAM-1 concentration, coronary artery calcium (CAC), and common and internal carotid intima medial thickness (IMT). Methods and Results: 3550 black and white Coronary Artery Risk Development in Young Adults (CARDIA) Study subjects who participated in the year 15 and/or 20 examinations and were part of the Young Adult Longitudinal Study of Antioxidants (YALTA) ancillary study were included in this analysis. In whites, rs5498 was significantly associated with sICAM-1 (p< 0.001) and each G-allele of rs5498 was associated with 5% higher sICAM-1 concentration. In blacks, each C-allele of rs5490 was associated with 6% higher sICAM-1 level; this SNP was in strong linkage disequilibrium with rs5491, a functional variant. Subclinical measurements of atherosclerosis in either year 15 or year 20 were not significantly related to ICAM1 SNPs. Conclusions: In CARDIA, ICAM1 DNA segment variants were associated with sICAM-1 protein level including the novel finding that levels differ by the functional variant rs5491. However, ICAM1 SNPs were not strongly related to either IMT or CAC. Our findings in CARDIA suggest that ICAM1 variants are not major early contributors to subclinical atherosclerosis.

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