Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas

Ping Yang, Thomas M. Kollmeyer, Kristin Buckner, William Bamlet, Karla V. Ballman, Robert Brian Jenkins

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

BACKGROUND. Deletions of 19q have been associated with gliomas, especially oligodendrogliomas. In addition, cases with oligodendrogliomas with the 19q deletion have been observed to have a better survival compared with cases without the 19q deletion. The authors have previously described a 150-kilobase minimal deletion region in gliomas that maps to 19q13.33 and contains 3 novel candidate genes (GLTSCR1, EHD2, and GLTSCR2). METHODS. The authors performed an association study using 141 cases with gliomas (61 cases with astrocytomas, 40 cases with oligodendrogliomas, 40 cases with mixed oligoastrocytomas) and 108 general controls. They evaluated 7 single nucleotide polymorphisms (SNPs) in 6 genes within and nearby the minimal 19q deletion region (ERCC2, RAI, ASE-1, ERCC1, GLTSCR1, and LIG1). RESULTS. The prevalence of a germline GLTSCR1-exon-1 T allele (SNP rs1035938) was 40% in cases with oligodendrogliomas compared with 27% in controls (P = 0.029), and the prevalence of an ERCC2-exon-22 T allele (SNP rs1052555) was 35% in cases with oligodendrogliomas compared with 18% in controls (P = 0.043). One high-risk and 1 low-risk haplotype were associated with oligodendroglioma development (P = 0.003 and 0.026, respectively). Cases with oligodendrogliomas with the 19q deletion had a significantly higher frequency of the GLTSCR1-exon-1 T allele compared with cases without the 19q deletion (P = 0.01). It was noteworthy that cases with gliomas who were homozygous for the GLTSCR1-exon-1 T allele had a significantly better survival: 77% and 68% survival at 2 and 5 years compared with 56% and 34% for other genotypes (P = 0.02, log-rank test). Multivariable analysis identified grade, age, and the GLTSCR1-exon-1 and ERCC2-exon-22 genotypes as independent predictors for survival. CONCLUSIONS. These results suggested that alterations in GLTSCR1 (or a closely linked gene) were associated with the development and progression of oligodendroglioma.

Original languageEnglish (US)
Pages (from-to)2363-2372
Number of pages10
JournalCancer
Volume103
Issue number11
DOIs
StatePublished - Jun 1 2005

Fingerprint

Oligodendroglioma
Exons
Glioma
Alleles
Single Nucleotide Polymorphism
Astrocytoma
Genotype
Genes
Haplotypes

Keywords

  • Astrocytoma
  • Chromosome 19q deletion
  • Glioma
  • Linkage disequilibrium
  • Oligodendroglioma
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas. / Yang, Ping; Kollmeyer, Thomas M.; Buckner, Kristin; Bamlet, William; Ballman, Karla V.; Jenkins, Robert Brian.

In: Cancer, Vol. 103, No. 11, 01.06.2005, p. 2363-2372.

Research output: Contribution to journalArticle

Yang, Ping ; Kollmeyer, Thomas M. ; Buckner, Kristin ; Bamlet, William ; Ballman, Karla V. ; Jenkins, Robert Brian. / Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas. In: Cancer. 2005 ; Vol. 103, No. 11. pp. 2363-2372.
@article{50b32630280f47aaa3af1f4b59fc5c21,
title = "Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas",
abstract = "BACKGROUND. Deletions of 19q have been associated with gliomas, especially oligodendrogliomas. In addition, cases with oligodendrogliomas with the 19q deletion have been observed to have a better survival compared with cases without the 19q deletion. The authors have previously described a 150-kilobase minimal deletion region in gliomas that maps to 19q13.33 and contains 3 novel candidate genes (GLTSCR1, EHD2, and GLTSCR2). METHODS. The authors performed an association study using 141 cases with gliomas (61 cases with astrocytomas, 40 cases with oligodendrogliomas, 40 cases with mixed oligoastrocytomas) and 108 general controls. They evaluated 7 single nucleotide polymorphisms (SNPs) in 6 genes within and nearby the minimal 19q deletion region (ERCC2, RAI, ASE-1, ERCC1, GLTSCR1, and LIG1). RESULTS. The prevalence of a germline GLTSCR1-exon-1 T allele (SNP rs1035938) was 40{\%} in cases with oligodendrogliomas compared with 27{\%} in controls (P = 0.029), and the prevalence of an ERCC2-exon-22 T allele (SNP rs1052555) was 35{\%} in cases with oligodendrogliomas compared with 18{\%} in controls (P = 0.043). One high-risk and 1 low-risk haplotype were associated with oligodendroglioma development (P = 0.003 and 0.026, respectively). Cases with oligodendrogliomas with the 19q deletion had a significantly higher frequency of the GLTSCR1-exon-1 T allele compared with cases without the 19q deletion (P = 0.01). It was noteworthy that cases with gliomas who were homozygous for the GLTSCR1-exon-1 T allele had a significantly better survival: 77{\%} and 68{\%} survival at 2 and 5 years compared with 56{\%} and 34{\%} for other genotypes (P = 0.02, log-rank test). Multivariable analysis identified grade, age, and the GLTSCR1-exon-1 and ERCC2-exon-22 genotypes as independent predictors for survival. CONCLUSIONS. These results suggested that alterations in GLTSCR1 (or a closely linked gene) were associated with the development and progression of oligodendroglioma.",
keywords = "Astrocytoma, Chromosome 19q deletion, Glioma, Linkage disequilibrium, Oligodendroglioma, Single nucleotide polymorphisms",
author = "Ping Yang and Kollmeyer, {Thomas M.} and Kristin Buckner and William Bamlet and Ballman, {Karla V.} and Jenkins, {Robert Brian}",
year = "2005",
month = "6",
day = "1",
doi = "10.1002/cncr.21028",
language = "English (US)",
volume = "103",
pages = "2363--2372",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "11",

}

TY - JOUR

T1 - Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas

AU - Yang, Ping

AU - Kollmeyer, Thomas M.

AU - Buckner, Kristin

AU - Bamlet, William

AU - Ballman, Karla V.

AU - Jenkins, Robert Brian

PY - 2005/6/1

Y1 - 2005/6/1

N2 - BACKGROUND. Deletions of 19q have been associated with gliomas, especially oligodendrogliomas. In addition, cases with oligodendrogliomas with the 19q deletion have been observed to have a better survival compared with cases without the 19q deletion. The authors have previously described a 150-kilobase minimal deletion region in gliomas that maps to 19q13.33 and contains 3 novel candidate genes (GLTSCR1, EHD2, and GLTSCR2). METHODS. The authors performed an association study using 141 cases with gliomas (61 cases with astrocytomas, 40 cases with oligodendrogliomas, 40 cases with mixed oligoastrocytomas) and 108 general controls. They evaluated 7 single nucleotide polymorphisms (SNPs) in 6 genes within and nearby the minimal 19q deletion region (ERCC2, RAI, ASE-1, ERCC1, GLTSCR1, and LIG1). RESULTS. The prevalence of a germline GLTSCR1-exon-1 T allele (SNP rs1035938) was 40% in cases with oligodendrogliomas compared with 27% in controls (P = 0.029), and the prevalence of an ERCC2-exon-22 T allele (SNP rs1052555) was 35% in cases with oligodendrogliomas compared with 18% in controls (P = 0.043). One high-risk and 1 low-risk haplotype were associated with oligodendroglioma development (P = 0.003 and 0.026, respectively). Cases with oligodendrogliomas with the 19q deletion had a significantly higher frequency of the GLTSCR1-exon-1 T allele compared with cases without the 19q deletion (P = 0.01). It was noteworthy that cases with gliomas who were homozygous for the GLTSCR1-exon-1 T allele had a significantly better survival: 77% and 68% survival at 2 and 5 years compared with 56% and 34% for other genotypes (P = 0.02, log-rank test). Multivariable analysis identified grade, age, and the GLTSCR1-exon-1 and ERCC2-exon-22 genotypes as independent predictors for survival. CONCLUSIONS. These results suggested that alterations in GLTSCR1 (or a closely linked gene) were associated with the development and progression of oligodendroglioma.

AB - BACKGROUND. Deletions of 19q have been associated with gliomas, especially oligodendrogliomas. In addition, cases with oligodendrogliomas with the 19q deletion have been observed to have a better survival compared with cases without the 19q deletion. The authors have previously described a 150-kilobase minimal deletion region in gliomas that maps to 19q13.33 and contains 3 novel candidate genes (GLTSCR1, EHD2, and GLTSCR2). METHODS. The authors performed an association study using 141 cases with gliomas (61 cases with astrocytomas, 40 cases with oligodendrogliomas, 40 cases with mixed oligoastrocytomas) and 108 general controls. They evaluated 7 single nucleotide polymorphisms (SNPs) in 6 genes within and nearby the minimal 19q deletion region (ERCC2, RAI, ASE-1, ERCC1, GLTSCR1, and LIG1). RESULTS. The prevalence of a germline GLTSCR1-exon-1 T allele (SNP rs1035938) was 40% in cases with oligodendrogliomas compared with 27% in controls (P = 0.029), and the prevalence of an ERCC2-exon-22 T allele (SNP rs1052555) was 35% in cases with oligodendrogliomas compared with 18% in controls (P = 0.043). One high-risk and 1 low-risk haplotype were associated with oligodendroglioma development (P = 0.003 and 0.026, respectively). Cases with oligodendrogliomas with the 19q deletion had a significantly higher frequency of the GLTSCR1-exon-1 T allele compared with cases without the 19q deletion (P = 0.01). It was noteworthy that cases with gliomas who were homozygous for the GLTSCR1-exon-1 T allele had a significantly better survival: 77% and 68% survival at 2 and 5 years compared with 56% and 34% for other genotypes (P = 0.02, log-rank test). Multivariable analysis identified grade, age, and the GLTSCR1-exon-1 and ERCC2-exon-22 genotypes as independent predictors for survival. CONCLUSIONS. These results suggested that alterations in GLTSCR1 (or a closely linked gene) were associated with the development and progression of oligodendroglioma.

KW - Astrocytoma

KW - Chromosome 19q deletion

KW - Glioma

KW - Linkage disequilibrium

KW - Oligodendroglioma

KW - Single nucleotide polymorphisms

UR - http://www.scopus.com/inward/record.url?scp=18844461918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18844461918&partnerID=8YFLogxK

U2 - 10.1002/cncr.21028

DO - 10.1002/cncr.21028

M3 - Article

C2 - 15834925

AN - SCOPUS:18844461918

VL - 103

SP - 2363

EP - 2372

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 11

ER -