Polymorphisms in DNA repair genes and risk of non-hodgkin lymphoma in a pooled analysis of three studies

Min Shen, Idan Menashe, Lindsay M. Morton, Yawei Zhang, Bruce Armstrong, Sophia S. Wang, Qing Lan, Patricia Hartge, Mark P. Purdue, James R Cerhan, Andrew Grulich, Wendy Cozen, Meredith Yeager, Theodore R. Holford, Claire M. Vajdic, Scott Davis, Brian Leaderer, Anne Kricker, Richard K. Severson, Shelia H. ZahmNilanjan Chatterjee, Nathaniel Rothman, Stephen J. Chanock, Tongzhang Zheng

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Genetic variations in DNA repair genes are thought to play an important role in the pathogenesis and development of non-Hodgkin lymphoma (NHL). To further explore this hypothesis, we genotyped 319 tag single nucleotide polymorphisms (SNPs) in 27 DNA repair gene regions in 1946 cases and 1808 controls pooled from three population-based case-control studies of NHL in the US and Australia. Relative risks of NHL and NHL subtypes in relation to SNP genotypes were assessed using logistic regression. Associations of gene regions and pathways with NHL or NHL subtypes were explored using the minP and tail-strength statistics, respectively. Overall, genetic polymorphisms within the DNA repair pathway were associated with NHL (P = 0·005). Similar associations were seen with the double-strand break repair (P = 0·02) and nucleotide excision repair (P = 0·04) pathways. Five SNPs (BLM rs441399, RAD50 rs2237060, FAM82A2 rs2304583, ERCC3 rs4150506, and XRCC4 rs13178127) were particularly noteworthy because their gene regions were significantly associated with NHL or NHL subtypes (minP ≤ 0·05), or because of high level of statistical significance (P ≤ 0·005) and consistent findings across the three studies. These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalBritish Journal of Haematology
Volume151
Issue number3
DOIs
StatePublished - Nov 2010

Fingerprint

DNA Repair
Non-Hodgkin's Lymphoma
Genes
Single Nucleotide Polymorphism
Genetic Polymorphisms
Tail
Case-Control Studies
Logistic Models
Genotype

Keywords

  • DNA repair
  • Non-hodgkin lymphoma
  • pooled analysis
  • single nucleotide polymorphism

ASJC Scopus subject areas

  • Hematology

Cite this

Polymorphisms in DNA repair genes and risk of non-hodgkin lymphoma in a pooled analysis of three studies. / Shen, Min; Menashe, Idan; Morton, Lindsay M.; Zhang, Yawei; Armstrong, Bruce; Wang, Sophia S.; Lan, Qing; Hartge, Patricia; Purdue, Mark P.; Cerhan, James R; Grulich, Andrew; Cozen, Wendy; Yeager, Meredith; Holford, Theodore R.; Vajdic, Claire M.; Davis, Scott; Leaderer, Brian; Kricker, Anne; Severson, Richard K.; Zahm, Shelia H.; Chatterjee, Nilanjan; Rothman, Nathaniel; Chanock, Stephen J.; Zheng, Tongzhang.

In: British Journal of Haematology, Vol. 151, No. 3, 11.2010, p. 239-244.

Research output: Contribution to journalArticle

Shen, M, Menashe, I, Morton, LM, Zhang, Y, Armstrong, B, Wang, SS, Lan, Q, Hartge, P, Purdue, MP, Cerhan, JR, Grulich, A, Cozen, W, Yeager, M, Holford, TR, Vajdic, CM, Davis, S, Leaderer, B, Kricker, A, Severson, RK, Zahm, SH, Chatterjee, N, Rothman, N, Chanock, SJ & Zheng, T 2010, 'Polymorphisms in DNA repair genes and risk of non-hodgkin lymphoma in a pooled analysis of three studies', British Journal of Haematology, vol. 151, no. 3, pp. 239-244. https://doi.org/10.1111/j.1365-2141.2010.08364.x
Shen, Min ; Menashe, Idan ; Morton, Lindsay M. ; Zhang, Yawei ; Armstrong, Bruce ; Wang, Sophia S. ; Lan, Qing ; Hartge, Patricia ; Purdue, Mark P. ; Cerhan, James R ; Grulich, Andrew ; Cozen, Wendy ; Yeager, Meredith ; Holford, Theodore R. ; Vajdic, Claire M. ; Davis, Scott ; Leaderer, Brian ; Kricker, Anne ; Severson, Richard K. ; Zahm, Shelia H. ; Chatterjee, Nilanjan ; Rothman, Nathaniel ; Chanock, Stephen J. ; Zheng, Tongzhang. / Polymorphisms in DNA repair genes and risk of non-hodgkin lymphoma in a pooled analysis of three studies. In: British Journal of Haematology. 2010 ; Vol. 151, No. 3. pp. 239-244.
@article{8d6659a9383f476d944584cf3f896ac5,
title = "Polymorphisms in DNA repair genes and risk of non-hodgkin lymphoma in a pooled analysis of three studies",
abstract = "Genetic variations in DNA repair genes are thought to play an important role in the pathogenesis and development of non-Hodgkin lymphoma (NHL). To further explore this hypothesis, we genotyped 319 tag single nucleotide polymorphisms (SNPs) in 27 DNA repair gene regions in 1946 cases and 1808 controls pooled from three population-based case-control studies of NHL in the US and Australia. Relative risks of NHL and NHL subtypes in relation to SNP genotypes were assessed using logistic regression. Associations of gene regions and pathways with NHL or NHL subtypes were explored using the minP and tail-strength statistics, respectively. Overall, genetic polymorphisms within the DNA repair pathway were associated with NHL (P = 0·005). Similar associations were seen with the double-strand break repair (P = 0·02) and nucleotide excision repair (P = 0·04) pathways. Five SNPs (BLM rs441399, RAD50 rs2237060, FAM82A2 rs2304583, ERCC3 rs4150506, and XRCC4 rs13178127) were particularly noteworthy because their gene regions were significantly associated with NHL or NHL subtypes (minP ≤ 0·05), or because of high level of statistical significance (P ≤ 0·005) and consistent findings across the three studies. These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL.",
keywords = "DNA repair, Non-hodgkin lymphoma, pooled analysis, single nucleotide polymorphism",
author = "Min Shen and Idan Menashe and Morton, {Lindsay M.} and Yawei Zhang and Bruce Armstrong and Wang, {Sophia S.} and Qing Lan and Patricia Hartge and Purdue, {Mark P.} and Cerhan, {James R} and Andrew Grulich and Wendy Cozen and Meredith Yeager and Holford, {Theodore R.} and Vajdic, {Claire M.} and Scott Davis and Brian Leaderer and Anne Kricker and Severson, {Richard K.} and Zahm, {Shelia H.} and Nilanjan Chatterjee and Nathaniel Rothman and Chanock, {Stephen J.} and Tongzhang Zheng",
year = "2010",
month = "11",
doi = "10.1111/j.1365-2141.2010.08364.x",
language = "English (US)",
volume = "151",
pages = "239--244",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Polymorphisms in DNA repair genes and risk of non-hodgkin lymphoma in a pooled analysis of three studies

AU - Shen, Min

AU - Menashe, Idan

AU - Morton, Lindsay M.

AU - Zhang, Yawei

AU - Armstrong, Bruce

AU - Wang, Sophia S.

AU - Lan, Qing

AU - Hartge, Patricia

AU - Purdue, Mark P.

AU - Cerhan, James R

AU - Grulich, Andrew

AU - Cozen, Wendy

AU - Yeager, Meredith

AU - Holford, Theodore R.

AU - Vajdic, Claire M.

AU - Davis, Scott

AU - Leaderer, Brian

AU - Kricker, Anne

AU - Severson, Richard K.

AU - Zahm, Shelia H.

AU - Chatterjee, Nilanjan

AU - Rothman, Nathaniel

AU - Chanock, Stephen J.

AU - Zheng, Tongzhang

PY - 2010/11

Y1 - 2010/11

N2 - Genetic variations in DNA repair genes are thought to play an important role in the pathogenesis and development of non-Hodgkin lymphoma (NHL). To further explore this hypothesis, we genotyped 319 tag single nucleotide polymorphisms (SNPs) in 27 DNA repair gene regions in 1946 cases and 1808 controls pooled from three population-based case-control studies of NHL in the US and Australia. Relative risks of NHL and NHL subtypes in relation to SNP genotypes were assessed using logistic regression. Associations of gene regions and pathways with NHL or NHL subtypes were explored using the minP and tail-strength statistics, respectively. Overall, genetic polymorphisms within the DNA repair pathway were associated with NHL (P = 0·005). Similar associations were seen with the double-strand break repair (P = 0·02) and nucleotide excision repair (P = 0·04) pathways. Five SNPs (BLM rs441399, RAD50 rs2237060, FAM82A2 rs2304583, ERCC3 rs4150506, and XRCC4 rs13178127) were particularly noteworthy because their gene regions were significantly associated with NHL or NHL subtypes (minP ≤ 0·05), or because of high level of statistical significance (P ≤ 0·005) and consistent findings across the three studies. These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL.

AB - Genetic variations in DNA repair genes are thought to play an important role in the pathogenesis and development of non-Hodgkin lymphoma (NHL). To further explore this hypothesis, we genotyped 319 tag single nucleotide polymorphisms (SNPs) in 27 DNA repair gene regions in 1946 cases and 1808 controls pooled from three population-based case-control studies of NHL in the US and Australia. Relative risks of NHL and NHL subtypes in relation to SNP genotypes were assessed using logistic regression. Associations of gene regions and pathways with NHL or NHL subtypes were explored using the minP and tail-strength statistics, respectively. Overall, genetic polymorphisms within the DNA repair pathway were associated with NHL (P = 0·005). Similar associations were seen with the double-strand break repair (P = 0·02) and nucleotide excision repair (P = 0·04) pathways. Five SNPs (BLM rs441399, RAD50 rs2237060, FAM82A2 rs2304583, ERCC3 rs4150506, and XRCC4 rs13178127) were particularly noteworthy because their gene regions were significantly associated with NHL or NHL subtypes (minP ≤ 0·05), or because of high level of statistical significance (P ≤ 0·005) and consistent findings across the three studies. These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL.

KW - DNA repair

KW - Non-hodgkin lymphoma

KW - pooled analysis

KW - single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=78651468484&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78651468484&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.2010.08364.x

DO - 10.1111/j.1365-2141.2010.08364.x

M3 - Article

C2 - 20813000

AN - SCOPUS:78651468484

VL - 151

SP - 239

EP - 244

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 3

ER -