Polymorphism of the MHC class II Eb gene determines the protection against collagen-induced arthritis

M. A. Gonzalez-Gay, E. Zanelli, C. J. Krco, G. H. Nabozny, J. Hanson, M. M. Griffiths, H. S. Luthra, C. S. David

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Abstract

Collagen-induced arthritis (CIA) is an animal model of auto immune polyarthritis, sharing similarities with rheumatoid arthritis (RA). Paradoxally, susceptibility to mouse CIA is controlled by the H2A loci (DQ homologous) while RA is linked to HLA.DR genes (H2E homologous). We recently showed that the Eβ(d) molecule prevents CIA development in susceptible H2(q) mice. We addressed the question of whether H2Eb polymorphism will influence CIA incidence as HLA.DRB1 polymorphism does in RA. In F1 mice, only H2Eb(d) and H2Eb(s) molecules showed protection. Using recombinant B10.RDD (Eb(a/b)) mice, we found that CIA protection was mediated by the first domain of the Eβ(d) molecule. Using peptides covering the third hypervariable region of the Eβ chain, we found a perfect correlation between presentation of Eβ peptides by the H2A(q) molecule and protection on CIA. Therefore, the mechanism by which H2Eb protects against CIA seems to rely on the affinity of Eβ peptides for the H2A(q) molecule.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalImmunogenetics
Volume42
Issue number1
DOIs
StatePublished - 1995

Fingerprint

MHC Class II Genes
Experimental Arthritis
Rheumatoid Arthritis
Arthritis
Animal Models
Peptides
Incidence
Genes

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Gonzalez-Gay, M. A., Zanelli, E., Krco, C. J., Nabozny, G. H., Hanson, J., Griffiths, M. M., ... David, C. S. (1995). Polymorphism of the MHC class II Eb gene determines the protection against collagen-induced arthritis. Immunogenetics, 42(1), 35-40. https://doi.org/10.1007/BF00164985

Polymorphism of the MHC class II Eb gene determines the protection against collagen-induced arthritis. / Gonzalez-Gay, M. A.; Zanelli, E.; Krco, C. J.; Nabozny, G. H.; Hanson, J.; Griffiths, M. M.; Luthra, H. S.; David, C. S.

In: Immunogenetics, Vol. 42, No. 1, 1995, p. 35-40.

Research output: Contribution to journalArticle

Gonzalez-Gay, MA, Zanelli, E, Krco, CJ, Nabozny, GH, Hanson, J, Griffiths, MM, Luthra, HS & David, CS 1995, 'Polymorphism of the MHC class II Eb gene determines the protection against collagen-induced arthritis', Immunogenetics, vol. 42, no. 1, pp. 35-40. https://doi.org/10.1007/BF00164985
Gonzalez-Gay MA, Zanelli E, Krco CJ, Nabozny GH, Hanson J, Griffiths MM et al. Polymorphism of the MHC class II Eb gene determines the protection against collagen-induced arthritis. Immunogenetics. 1995;42(1):35-40. https://doi.org/10.1007/BF00164985
Gonzalez-Gay, M. A. ; Zanelli, E. ; Krco, C. J. ; Nabozny, G. H. ; Hanson, J. ; Griffiths, M. M. ; Luthra, H. S. ; David, C. S. / Polymorphism of the MHC class II Eb gene determines the protection against collagen-induced arthritis. In: Immunogenetics. 1995 ; Vol. 42, No. 1. pp. 35-40.
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