Polymorphism of Hh-1, the mouse hemopoietic histocompatibility locus

Richard M. Rembecki, Vinay Kumar, Chella S. David, Michael Bennett

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The major goal of these studies is to more fully assess the polymorphism of the hemopoietic histocompatibility (Hh) genetic system. H-2 homozygosity is required for optimal immunogenicity of bone marrow cell (BMC) grafts, and "hybrid resistance" to grafts of parental strain BMC by irradiated H-2 heterozygous F1 hybrid mice suggests that Hh-1 antigens are inherited recessively. The Hh-1 antigens are also expressed on other normal hematopoietic cells and lymphoid tumors, and natural killer cells are the effectors which mediate the elimination of BMC grafts in an Hh-specific manner. Previous studies have demonstrated three different antigens mapping to the Hh-1 locus near H-2D. We test the expression of Hh-1 on BMC of all nonrecombinant H-2 haplotypes of independent origin and H-2j, a presumed natural recombinant. Hh-1 typing is based on the pattern of growth and rejection in a panel of hosts. F1 hybrids with H-2b, H-2d, and H-2k are produced and used as donors and hosts to confirm the phenotype. Grafts of b-, d-, and j-haplotype marrow serve as prototypical examples of determinants that are provisionally designated as 1, 2, and 3, respectively. We describe a new determinant, 4, in the k haplotype. It is non-codominantly expressed, maps to H-2D, and is also expressed on H-2b BMC. NZW, H-2Z grafts exhibit a phenotype similar to k, but express a unique determinant 5 which can be distinguished from determinant 4. This additional determinant is also expressed by the b haplotype. The d, f, and p haplotypes all express determinant 2, and grafts of j-haplotype marrow are found to express determinants 2 and 5 in addition to determinant 3. The q and r haplotypes are null for all known determinants. Finally, we describe a phenotype which is a new combination of previously described determinants: s-haplotype grafts express determinants 1, 2, and 4. The polymorphism of Hh-1 detected thus far consists of seven alleles which are combinations of five distinct determinants.

Original languageEnglish (US)
Pages (from-to)158-170
Number of pages13
JournalImmunogenetics
Volume28
Issue number3
DOIs
StatePublished - Sep 1988

Fingerprint

Histocompatibility
Haplotypes
Bone Marrow Cells
Transplants
Phenotype
Bone Marrow
Histocompatibility Antigens
Natural Killer Cells
Alleles
Lymphocytes
Antigens
Growth

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Rembecki, R. M., Kumar, V., David, C. S., & Bennett, M. (1988). Polymorphism of Hh-1, the mouse hemopoietic histocompatibility locus. Immunogenetics, 28(3), 158-170. https://doi.org/10.1007/BF00375855

Polymorphism of Hh-1, the mouse hemopoietic histocompatibility locus. / Rembecki, Richard M.; Kumar, Vinay; David, Chella S.; Bennett, Michael.

In: Immunogenetics, Vol. 28, No. 3, 09.1988, p. 158-170.

Research output: Contribution to journalArticle

Rembecki, RM, Kumar, V, David, CS & Bennett, M 1988, 'Polymorphism of Hh-1, the mouse hemopoietic histocompatibility locus', Immunogenetics, vol. 28, no. 3, pp. 158-170. https://doi.org/10.1007/BF00375855
Rembecki, Richard M. ; Kumar, Vinay ; David, Chella S. ; Bennett, Michael. / Polymorphism of Hh-1, the mouse hemopoietic histocompatibility locus. In: Immunogenetics. 1988 ; Vol. 28, No. 3. pp. 158-170.
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