Polymorphism in tumor necrosis factor-related apoptosis-inducing ligand receptor 1 is associated with poor viral response to interferon-based hepatitis C virus therapy in HIV/hepatitis C virus-coinfected individuals

Stacey Rizza, Nathan W Cummins, David N. Rider, Sahar Saeed, Marina B. Klein, Andrew David Badley

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective(S): HIV/hepatitis C virus (HCV) coinfection causes accelerated liver disease compared to HCV monoinfection, and only 30-60% of HIV/HCV-coinfected individuals respond to HCV therapy with pegylated interferon and ribavirin. There are currently no biomarkers that predict treatment response in these coinfected patients. Design: We investigated whether there is an association between HCV treatment response and SNPs of apoptosis-related genes during HIV/HCV coinfection. Method: Genomic DNA from 53 HIV/HCV-coinfected individuals was analyzed for 82 SNPs of 10 apoptosis-related genes. Results: We found that the presence of the rs4242392 SNP in tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A), which encodes for tumor necrosis factor-related apoptosis-inducing ligand receptor 1, predicts poor outcome to HCV therapy, in HIV/HCV-co-infected patients [odds ratio 5.91 (95% confidence interval 1.63-21.38, P = 0.007)]. Conclusion: The rs4242392 SNP of the tumor necrosis factor-related apoptosis-inducing ligand receptor 1 gene predicted poor interferon-based HCV treatment response in HIV/HCV-coinfected patients.

Original languageEnglish (US)
Pages (from-to)2637-2644
Number of pages8
JournalAIDS
Volume24
Issue number17
DOIs
StatePublished - Nov 13 2010

Fingerprint

Hepacivirus
Interferons
Tumor Necrosis Factor-alpha
HIV
Apoptosis
Ligands
Single Nucleotide Polymorphism
Therapeutics
Coinfection
TNF-Related Apoptosis-Inducing Ligand Receptors
Genes
Ribavirin
Liver Diseases
Biomarkers
Odds Ratio
Confidence Intervals
DNA

Keywords

  • apoptosis
  • hepatitis C virus
  • HIV/hepatitis C virus
  • polymorphism
  • treatment response
  • tumor necrosis factor-related apoptosis-inducing ligand receptor 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases
  • Medicine(all)

Cite this

@article{cede5209a5df418b9d968eb444a411cb,
title = "Polymorphism in tumor necrosis factor-related apoptosis-inducing ligand receptor 1 is associated with poor viral response to interferon-based hepatitis C virus therapy in HIV/hepatitis C virus-coinfected individuals",
abstract = "Objective(S): HIV/hepatitis C virus (HCV) coinfection causes accelerated liver disease compared to HCV monoinfection, and only 30-60{\%} of HIV/HCV-coinfected individuals respond to HCV therapy with pegylated interferon and ribavirin. There are currently no biomarkers that predict treatment response in these coinfected patients. Design: We investigated whether there is an association between HCV treatment response and SNPs of apoptosis-related genes during HIV/HCV coinfection. Method: Genomic DNA from 53 HIV/HCV-coinfected individuals was analyzed for 82 SNPs of 10 apoptosis-related genes. Results: We found that the presence of the rs4242392 SNP in tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A), which encodes for tumor necrosis factor-related apoptosis-inducing ligand receptor 1, predicts poor outcome to HCV therapy, in HIV/HCV-co-infected patients [odds ratio 5.91 (95{\%} confidence interval 1.63-21.38, P = 0.007)]. Conclusion: The rs4242392 SNP of the tumor necrosis factor-related apoptosis-inducing ligand receptor 1 gene predicted poor interferon-based HCV treatment response in HIV/HCV-coinfected patients.",
keywords = "apoptosis, hepatitis C virus, HIV/hepatitis C virus, polymorphism, treatment response, tumor necrosis factor-related apoptosis-inducing ligand receptor 1",
author = "Stacey Rizza and Cummins, {Nathan W} and Rider, {David N.} and Sahar Saeed and Klein, {Marina B.} and Badley, {Andrew David}",
year = "2010",
month = "11",
day = "13",
doi = "10.1097/QAD.0b013e32833eacfd",
language = "English (US)",
volume = "24",
pages = "2637--2644",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "17",

}

TY - JOUR

T1 - Polymorphism in tumor necrosis factor-related apoptosis-inducing ligand receptor 1 is associated with poor viral response to interferon-based hepatitis C virus therapy in HIV/hepatitis C virus-coinfected individuals

AU - Rizza, Stacey

AU - Cummins, Nathan W

AU - Rider, David N.

AU - Saeed, Sahar

AU - Klein, Marina B.

AU - Badley, Andrew David

PY - 2010/11/13

Y1 - 2010/11/13

N2 - Objective(S): HIV/hepatitis C virus (HCV) coinfection causes accelerated liver disease compared to HCV monoinfection, and only 30-60% of HIV/HCV-coinfected individuals respond to HCV therapy with pegylated interferon and ribavirin. There are currently no biomarkers that predict treatment response in these coinfected patients. Design: We investigated whether there is an association between HCV treatment response and SNPs of apoptosis-related genes during HIV/HCV coinfection. Method: Genomic DNA from 53 HIV/HCV-coinfected individuals was analyzed for 82 SNPs of 10 apoptosis-related genes. Results: We found that the presence of the rs4242392 SNP in tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A), which encodes for tumor necrosis factor-related apoptosis-inducing ligand receptor 1, predicts poor outcome to HCV therapy, in HIV/HCV-co-infected patients [odds ratio 5.91 (95% confidence interval 1.63-21.38, P = 0.007)]. Conclusion: The rs4242392 SNP of the tumor necrosis factor-related apoptosis-inducing ligand receptor 1 gene predicted poor interferon-based HCV treatment response in HIV/HCV-coinfected patients.

AB - Objective(S): HIV/hepatitis C virus (HCV) coinfection causes accelerated liver disease compared to HCV monoinfection, and only 30-60% of HIV/HCV-coinfected individuals respond to HCV therapy with pegylated interferon and ribavirin. There are currently no biomarkers that predict treatment response in these coinfected patients. Design: We investigated whether there is an association between HCV treatment response and SNPs of apoptosis-related genes during HIV/HCV coinfection. Method: Genomic DNA from 53 HIV/HCV-coinfected individuals was analyzed for 82 SNPs of 10 apoptosis-related genes. Results: We found that the presence of the rs4242392 SNP in tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A), which encodes for tumor necrosis factor-related apoptosis-inducing ligand receptor 1, predicts poor outcome to HCV therapy, in HIV/HCV-co-infected patients [odds ratio 5.91 (95% confidence interval 1.63-21.38, P = 0.007)]. Conclusion: The rs4242392 SNP of the tumor necrosis factor-related apoptosis-inducing ligand receptor 1 gene predicted poor interferon-based HCV treatment response in HIV/HCV-coinfected patients.

KW - apoptosis

KW - hepatitis C virus

KW - HIV/hepatitis C virus

KW - polymorphism

KW - treatment response

KW - tumor necrosis factor-related apoptosis-inducing ligand receptor 1

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