Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-hispanic white women: The Ovarian Cancer Association Consortium

Catherine M. Phelan; Ya Yu Tsai; Ellen L. Goode; Robert A. Vierkant; Brooke L. Fridley; Jonathan Beesley; Xiao Qing Chen; Penelope M. Webb; Stephen Chanock; Daniel W. Cramer; Kirsten Moysich; Robert P. Edwards; Jenny Chang-Claude; Montserrat Garcia-Closas; Hannah Yang; Shan Wang-Gohrke; Rebecca Hein; Adele C. Green; Jolanta Lissowska; Michael E. Carney; Galina Lurie; Lynne R. Wilkens; Roberta B. Ness; Celeste Leigh Pearce; Anna H. Wu; David J. Van Den Berg; Daniel O. Stram; Kathryn L. Terry; David C. Whiteman; Alice S. Whittemore; Richard A. DiCioccio; Valerie McGuire; Jennifer A. Doherty; Mary Anne Rossing; Hoda Anton-Culver; Argyrios Ziogas; Claus Hogdall; Estrid Hogdall; Susanne Krüger Kjaer; Jan Blaakaer; Lydia Quaye; Susan J. Ramus; Ian Jacobs; Honglin Song; Paul D.P. Pharoah; Edwin S. Iversen; Jeffrey R. Marks; Malcolm C. Pike; Simon A. Gayther; Julie M. Cunningham; Marc T. Goodman; Joellen M. Schildkraut; Georgia Chenevix-Trench; Andrew Berchuck; Thomas A. Sellers

doi:10.1158/1055-9965.EPI-09-0861

Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-hispanic white women: The Ovarian Cancer Association Consortium

Catherine M. Phelan, Ya Yu Tsai, Ellen L. Goode, Robert A. Vierkant, Brooke L. Fridley, Jonathan Beesley, Xiao Qing Chen, Penelope M. Webb, Stephen Chanock, Daniel W. Cramer, Kirsten Moysich, Robert P. Edwards, Jenny Chang-Claude, Montserrat Garcia-Closas, Hannah Yang, Shan Wang-Gohrke, Rebecca Hein, Adele C. Green, Jolanta Lissowska, Michael E. CarneyGalina Lurie, Lynne R. Wilkens, Roberta B. Ness, Celeste Leigh Pearce, Anna H. Wu, David J. Van Den Berg, Daniel O. Stram, Kathryn L. Terry, David C. Whiteman, Alice S. Whittemore, Richard A. DiCioccio, Valerie McGuire, Jennifer A. Doherty, Mary Anne Rossing, Hoda Anton-Culver, Argyrios Ziogas, Claus Hogdall, Estrid Hogdall, Susanne Krüger Kjaer, Jan Blaakaer, Lydia Quaye, Susan J. Ramus, Ian Jacobs, Honglin Song, Paul D.P. Pharoah, Edwin S. Iversen, Jeffrey R. Marks, Malcolm C. Pike, Simon A. Gayther, Julie M. Cunningham, Marc T. Goodman, Joellen M. Schildkraut, Georgia Chenevix-Trench, Andrew Berchuck, Thomas A. Sellers

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Abstract

Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for hetero geneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.

Original language	English (US)
Pages (from-to)	600-604
Number of pages	5
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	19
Issue number	2
DOIs	https://doi.org/10.1158/1055-9965.EPI-09-0861
State	Published - Feb 2010

ASJC Scopus subject areas

General Medicine

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Phelan, C. M., Tsai, Y. Y., Goode, E. L., Vierkant, R. A., Fridley, B. L., Beesley, J., Chen, X. Q., Webb, P. M., Chanock, S., Cramer, D. W., Moysich, K., Edwards, R. P., Chang-Claude, J., Garcia-Closas, M., Yang, H., Wang-Gohrke, S., Hein, R., Green, A. C., Lissowska, J., ... Sellers, T. A. (2010). Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-hispanic white women: The Ovarian Cancer Association Consortium. Cancer Epidemiology Biomarkers and Prevention, 19(2), 600-604. https://doi.org/10.1158/1055-9965.EPI-09-0861

Phelan, CM, Tsai, YY, Goode, EL, Vierkant, RA, Fridley, BL, Beesley, J, Chen, XQ, Webb, PM, Chanock, S, Cramer, DW, Moysich, K, Edwards, RP, Chang-Claude, J, Garcia-Closas, M, Yang, H, Wang-Gohrke, S, Hein, R, Green, AC, Lissowska, J, Carney, ME, Lurie, G, Wilkens, LR, Ness, RB, Pearce, CL, Wu, AH, Van Den Berg, DJ, Stram, DO, Terry, KL, Whiteman, DC, Whittemore, AS, DiCioccio, RA, McGuire, V, Doherty, JA, Rossing, MA, Anton-Culver, H, Ziogas, A, Hogdall, C, Hogdall, E, Kjaer, SK, Blaakaer, J, Quaye, L, Ramus, SJ, Jacobs, I, Song, H, Pharoah, PDP, Iversen, ES, Marks, JR, Pike, MC, Gayther, SA, Cunningham, JM, Goodman, MT, Schildkraut, JM, Chenevix-Trench, G, Berchuck, A & Sellers, TA 2010, 'Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-hispanic white women: The Ovarian Cancer Association Consortium', Cancer Epidemiology Biomarkers and Prevention, vol. 19, no. 2, pp. 600-604. https://doi.org/10.1158/1055-9965.EPI-09-0861

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title = "Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-hispanic white women: The Ovarian Cancer Association Consortium",

abstract = "Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for hetero geneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.",

author = "Phelan, {Catherine M.} and Tsai, {Ya Yu} and Goode, {Ellen L.} and Vierkant, {Robert A.} and Fridley, {Brooke L.} and Jonathan Beesley and Chen, {Xiao Qing} and Webb, {Penelope M.} and Stephen Chanock and Cramer, {Daniel W.} and Kirsten Moysich and Edwards, {Robert P.} and Jenny Chang-Claude and Montserrat Garcia-Closas and Hannah Yang and Shan Wang-Gohrke and Rebecca Hein and Green, {Adele C.} and Jolanta Lissowska and Carney, {Michael E.} and Galina Lurie and Wilkens, {Lynne R.} and Ness, {Roberta B.} and Pearce, {Celeste Leigh} and Wu, {Anna H.} and {Van Den Berg}, {David J.} and Stram, {Daniel O.} and Terry, {Kathryn L.} and Whiteman, {David C.} and Whittemore, {Alice S.} and DiCioccio, {Richard A.} and Valerie McGuire and Doherty, {Jennifer A.} and Rossing, {Mary Anne} and Hoda Anton-Culver and Argyrios Ziogas and Claus Hogdall and Estrid Hogdall and Kjaer, {Susanne Kr{\"u}ger} and Jan Blaakaer and Lydia Quaye and Ramus, {Susan J.} and Ian Jacobs and Honglin Song and Pharoah, {Paul D.P.} and Iversen, {Edwin S.} and Marks, {Jeffrey R.} and Pike, {Malcolm C.} and Gayther, {Simon A.} and Cunningham, {Julie M.} and Goodman, {Marc T.} and Schildkraut, {Joellen M.} and Georgia Chenevix-Trench and Andrew Berchuck and Sellers, {Thomas A.}",

year = "2010",

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doi = "10.1158/1055-9965.EPI-09-0861",

language = "English (US)",

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T1 - Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-hispanic white women

T2 - The Ovarian Cancer Association Consortium

AU - Phelan, Catherine M.

AU - Tsai, Ya Yu

AU - Goode, Ellen L.

AU - Vierkant, Robert A.

AU - Fridley, Brooke L.

AU - Beesley, Jonathan

AU - Chen, Xiao Qing

AU - Webb, Penelope M.

AU - Chanock, Stephen

AU - Cramer, Daniel W.

AU - Moysich, Kirsten

AU - Edwards, Robert P.

AU - Chang-Claude, Jenny

AU - Garcia-Closas, Montserrat

AU - Yang, Hannah

AU - Wang-Gohrke, Shan

AU - Hein, Rebecca

AU - Green, Adele C.

AU - Lissowska, Jolanta

AU - Carney, Michael E.

AU - Lurie, Galina

AU - Wilkens, Lynne R.

AU - Ness, Roberta B.

AU - Pearce, Celeste Leigh

AU - Wu, Anna H.

AU - Van Den Berg, David J.

AU - Stram, Daniel O.

AU - Terry, Kathryn L.

AU - Whiteman, David C.

AU - Whittemore, Alice S.

AU - DiCioccio, Richard A.

AU - McGuire, Valerie

AU - Doherty, Jennifer A.

AU - Rossing, Mary Anne

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Hogdall, Claus

AU - Hogdall, Estrid

AU - Kjaer, Susanne Krüger

AU - Blaakaer, Jan

AU - Quaye, Lydia

AU - Ramus, Susan J.

AU - Jacobs, Ian

AU - Song, Honglin

AU - Pharoah, Paul D.P.

AU - Iversen, Edwin S.

AU - Marks, Jeffrey R.

AU - Pike, Malcolm C.

AU - Gayther, Simon A.

AU - Cunningham, Julie M.

AU - Goodman, Marc T.

AU - Schildkraut, Joellen M.

AU - Chenevix-Trench, Georgia

AU - Berchuck, Andrew

AU - Sellers, Thomas A.

PY - 2010/2

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N2 - Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for hetero geneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.

AB - Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for hetero geneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.

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Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-hispanic white women: The Ovarian Cancer Association Consortium

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