Polymorphism and diversity in the Tla gene system

Kazushige Yokoyama; Elisabeth Stockert; Larry R. Pease; Yuichi Obata; Lloyd J. Old; Stanley G. Nathenson

doi:10.1007/BF00364386

Polymorphism and diversity in the Tla gene system

Kazushige Yokoyama, Elisabeth Stockert, Larry R. Pease, Yuichi Obata, Lloyd J. Old, Stanley G. Nathenson

Immunology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The TL products of mouse strains carrying the Tla^a, Tla^a, and Tla^e haplotypes were analyzed by comparative peptide mapping. As expected from their known serologic differences, TL antigens from strain A (Tla^a), A.CA strain (Tla^d) and P/J strain (Tla^e) mice showed structural variation. However, comparable variations were also observed in the TL product derived from strains expressing the serologically indistinguishable Tla^a allele (A, NFS/N, SJL/J, C57BR, and C58) demonstrating additional unexpected polymorphism in the TL system. When compared with the structural diversity of the H-2 K and D gene products, the structural variation of the TL antigens was small. Taken together, the results of our analysis of the TL products suggest that Tla polymorphism is more extensive than previously thought; however, the structural diversity of the products is still low compared with K and D gene products.

Original language	English (US)
Pages (from-to)	445-451
Number of pages	7
Journal	Immunogenetics
Volume	18
Issue number	5
DOIs	https://doi.org/10.1007/BF00364386
State	Published - Nov 1983

ASJC Scopus subject areas

Immunology
Genetics

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10.1007/BF00364386

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title = "Polymorphism and diversity in the Tla gene system",

abstract = "The TL products of mouse strains carrying the Tlaa, Tlaa, and Tlae haplotypes were analyzed by comparative peptide mapping. As expected from their known serologic differences, TL antigens from strain A (Tlaa), A.CA strain (Tlad) and P/J strain (Tlae) mice showed structural variation. However, comparable variations were also observed in the TL product derived from strains expressing the serologically indistinguishable Tlaa allele (A, NFS/N, SJL/J, C57BR, and C58) demonstrating additional unexpected polymorphism in the TL system. When compared with the structural diversity of the H-2 K and D gene products, the structural variation of the TL antigens was small. Taken together, the results of our analysis of the TL products suggest that Tla polymorphism is more extensive than previously thought; however, the structural diversity of the products is still low compared with K and D gene products.",

author = "Kazushige Yokoyama and Elisabeth Stockert and Pease, {Larry R.} and Yuichi Obata and Old, {Lloyd J.} and Nathenson, {Stanley G.}",

year = "1983",

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T1 - Polymorphism and diversity in the Tla gene system

AU - Yokoyama, Kazushige

AU - Stockert, Elisabeth

AU - Pease, Larry R.

AU - Obata, Yuichi

AU - Old, Lloyd J.

AU - Nathenson, Stanley G.

PY - 1983/11

Y1 - 1983/11

N2 - The TL products of mouse strains carrying the Tlaa, Tlaa, and Tlae haplotypes were analyzed by comparative peptide mapping. As expected from their known serologic differences, TL antigens from strain A (Tlaa), A.CA strain (Tlad) and P/J strain (Tlae) mice showed structural variation. However, comparable variations were also observed in the TL product derived from strains expressing the serologically indistinguishable Tlaa allele (A, NFS/N, SJL/J, C57BR, and C58) demonstrating additional unexpected polymorphism in the TL system. When compared with the structural diversity of the H-2 K and D gene products, the structural variation of the TL antigens was small. Taken together, the results of our analysis of the TL products suggest that Tla polymorphism is more extensive than previously thought; however, the structural diversity of the products is still low compared with K and D gene products.

AB - The TL products of mouse strains carrying the Tlaa, Tlaa, and Tlae haplotypes were analyzed by comparative peptide mapping. As expected from their known serologic differences, TL antigens from strain A (Tlaa), A.CA strain (Tlad) and P/J strain (Tlae) mice showed structural variation. However, comparable variations were also observed in the TL product derived from strains expressing the serologically indistinguishable Tlaa allele (A, NFS/N, SJL/J, C57BR, and C58) demonstrating additional unexpected polymorphism in the TL system. When compared with the structural diversity of the H-2 K and D gene products, the structural variation of the TL antigens was small. Taken together, the results of our analysis of the TL products suggest that Tla polymorphism is more extensive than previously thought; however, the structural diversity of the products is still low compared with K and D gene products.

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Polymorphism and diversity in the Tla gene system

Abstract

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