Polymorphism and diversity in the Tla gene system

Kazushige Yokoyama, Elisabeth Stockert, Larry R Pease, Yuichi Obata, Lloyd J. Old, Stanley G. Nathenson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The TL products of mouse strains carrying the Tlaa, Tlaa, and Tlae haplotypes were analyzed by comparative peptide mapping. As expected from their known serologic differences, TL antigens from strain A (Tlaa), A.CA strain (Tlad) and P/J strain (Tlae) mice showed structural variation. However, comparable variations were also observed in the TL product derived from strains expressing the serologically indistinguishable Tlaa allele (A, NFS/N, SJL/J, C57BR, and C58) demonstrating additional unexpected polymorphism in the TL system. When compared with the structural diversity of the H-2 K and D gene products, the structural variation of the TL antigens was small. Taken together, the results of our analysis of the TL products suggest that Tla polymorphism is more extensive than previously thought; however, the structural diversity of the products is still low compared with K and D gene products.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalImmunogenetics
Volume18
Issue number5
DOIs
StatePublished - Nov 1983
Externally publishedYes

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Peptide Mapping
Haplotypes
Genes
Alleles
thymus-leukemia antigens

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Yokoyama, K., Stockert, E., Pease, L. R., Obata, Y., Old, L. J., & Nathenson, S. G. (1983). Polymorphism and diversity in the Tla gene system. Immunogenetics, 18(5), 445-451. https://doi.org/10.1007/BF00364386

Polymorphism and diversity in the Tla gene system. / Yokoyama, Kazushige; Stockert, Elisabeth; Pease, Larry R; Obata, Yuichi; Old, Lloyd J.; Nathenson, Stanley G.

In: Immunogenetics, Vol. 18, No. 5, 11.1983, p. 445-451.

Research output: Contribution to journalArticle

Yokoyama, K, Stockert, E, Pease, LR, Obata, Y, Old, LJ & Nathenson, SG 1983, 'Polymorphism and diversity in the Tla gene system', Immunogenetics, vol. 18, no. 5, pp. 445-451. https://doi.org/10.1007/BF00364386
Yokoyama K, Stockert E, Pease LR, Obata Y, Old LJ, Nathenson SG. Polymorphism and diversity in the Tla gene system. Immunogenetics. 1983 Nov;18(5):445-451. https://doi.org/10.1007/BF00364386
Yokoyama, Kazushige ; Stockert, Elisabeth ; Pease, Larry R ; Obata, Yuichi ; Old, Lloyd J. ; Nathenson, Stanley G. / Polymorphism and diversity in the Tla gene system. In: Immunogenetics. 1983 ; Vol. 18, No. 5. pp. 445-451.
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