Polymorphic reticulosis: A reappraisal

John G. Strickler, Manuel F. Meneses, Thomas Matthew Habermann, Duane M. Ilstrup, John D. Earle, Thomas J. McDonald, Karen L. Chang, Lawrence M. Weiss

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We studied 18 patients (15 men and three women) evaluated for a destructive sinonasal lesion that had been diagnosed as "polymorphic reticulosis". The histologic features of each lesion were those of "angiocentric immunoproliferative lesions", characterized by atypical lymphoid infiltrates with polymorphous, angiocentric, and necrotic features; 13 were grade 2 and five were grade 3. The neoplastic cells in each patient had a T-cell phenotype. Epstein-Barr virus RNA was detected in the neoplastic cells of 17 of the 18 T-cell lesions. Initial treatment consisted of local radiation therapy in each patient, chemotherapy in two patients, and prednisone in another patient. Two patients were lost to follow-up and the other 16 had a median follow-up of 14 years, 2 months (range, 4 months to 32 years, 5 months). Four patients are alive and disease free, four patients died not of disease or complication of therapy, and eight patients died of disease. The Kaplan-Meier estimate of survival was 63% at 5 years and 50% at 15 years. Histologic progression of angiocentric immunoproliferative lesions from grade 2 to grade 3 was observed in two patients, and a correlation between angiocentric immunoproliferative grade and survival could not be detected. These data suggest that polymorphic reticulosis is an Epstein-Barr virus-related angiocentric T-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)659-665
Number of pages7
JournalHuman Pathology
Volume25
Issue number7
DOIs
StatePublished - 1994

Fingerprint

Lethal Midline Granuloma
Human Herpesvirus 4
T-Lymphocytes
Survival
T-Cell Lymphoma
Lost to Follow-Up
Kaplan-Meier Estimate
Prednisone

Keywords

  • angiocentric immunoproliferative lesion
  • angiocentric lymphoma
  • Epstein-Barr virus
  • peripheral T-cell lymphoma
  • polymorphic reticulosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Strickler, J. G., Meneses, M. F., Habermann, T. M., Ilstrup, D. M., Earle, J. D., McDonald, T. J., ... Weiss, L. M. (1994). Polymorphic reticulosis: A reappraisal. Human Pathology, 25(7), 659-665. https://doi.org/10.1016/0046-8177(94)90298-4

Polymorphic reticulosis : A reappraisal. / Strickler, John G.; Meneses, Manuel F.; Habermann, Thomas Matthew; Ilstrup, Duane M.; Earle, John D.; McDonald, Thomas J.; Chang, Karen L.; Weiss, Lawrence M.

In: Human Pathology, Vol. 25, No. 7, 1994, p. 659-665.

Research output: Contribution to journalArticle

Strickler, JG, Meneses, MF, Habermann, TM, Ilstrup, DM, Earle, JD, McDonald, TJ, Chang, KL & Weiss, LM 1994, 'Polymorphic reticulosis: A reappraisal', Human Pathology, vol. 25, no. 7, pp. 659-665. https://doi.org/10.1016/0046-8177(94)90298-4
Strickler JG, Meneses MF, Habermann TM, Ilstrup DM, Earle JD, McDonald TJ et al. Polymorphic reticulosis: A reappraisal. Human Pathology. 1994;25(7):659-665. https://doi.org/10.1016/0046-8177(94)90298-4
Strickler, John G. ; Meneses, Manuel F. ; Habermann, Thomas Matthew ; Ilstrup, Duane M. ; Earle, John D. ; McDonald, Thomas J. ; Chang, Karen L. ; Weiss, Lawrence M. / Polymorphic reticulosis : A reappraisal. In: Human Pathology. 1994 ; Vol. 25, No. 7. pp. 659-665.
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