Polymeric delivery vehicles for bone growth factors

Lichun Lu, Susan J. Peter, Georgios N. Stamatas, Antonios G. Mikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effects of polyethylene glycol (PEG) content and pH on in vitro transforming growth factor-β1 (TGF-β1) release kinetics and poly(DL-lactic-co-glycolic acid) (PLGA) degradation were studied, along with the effects of TGF-β1 released from the PLGA/PEG microparticles on the proliferation and differentiation of cultured primary rat marrow stromal cells. The release of TGF-β1 from the PLGA/PEG microparticles was increased by increasing the PEG content or buffer pH during the 28-day period. Increasing the PEG content also slightly increased PLGA degradation, while decreasing the pH significantly accelerated PLGA degradation. Significant increase in the alkaline phosphatase activity of cultured cell was observed at on optimal dosage of 1.0 ng/ml.

Original languageEnglish (US)
Title of host publicationAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
PublisherAmerican Chemical Society
Pages277-278
Number of pages2
Volume40
Edition1
StatePublished - Mar 1999
Externally publishedYes
EventProceedings of the 1999 ACS Anaheim Meeting - Anaheim, CA, USA
Duration: Mar 21 1999Mar 25 1999

Other

OtherProceedings of the 1999 ACS Anaheim Meeting
CityAnaheim, CA, USA
Period3/21/993/25/99

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Lu, L., Peter, S. J., Stamatas, G. N., & Mikos, A. G. (1999). Polymeric delivery vehicles for bone growth factors. In American Chemical Society, Polymer Preprints, Division of Polymer Chemistry (1 ed., Vol. 40, pp. 277-278). American Chemical Society.