Polymeric biomaterials: A history of use in musculoskeletal regenerative and reconstructive medicine

Wen Bin Zhang, Stephen Z D Cheng, Michael J Yaszemski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This chapter provides an overview of the application of synthetic polymeric biomaterials in musculoskeletal regenerative and reconstructive medicine with selected examples. Hydrogels capable of cell and growth factor delivery were assessed for injectable cartilage tissue engineering. Injectable composite scaffolds incorporating bone morphogenetic protein-2 (BMP-2) were developed to regenerate critical-sized defects in a rat femoral defect model. Advanced scaffold design was achieved by computer aided stereolithography. Nerve tubes with multiple parallel channels were investigated as guidance scaffolds for peripheral nerve and spinal cord regeneration. All of these demonstrated the versatility of synthetic polymers as multifunctional, interactive, and biodegradable bioscaffolds with virtually unlimited possibility for performance optimization through polymer and surface chemistry modification and physical manipulation.

Original languageEnglish (US)
Title of host publicationACS Symposium Series
PublisherAmerican Chemical Society
Pages165-182
Number of pages18
Volume1080
ISBN (Print)9780841226777
DOIs
StatePublished - 2011

Publication series

NameACS Symposium Series
Volume1080
ISSN (Print)00976156
ISSN (Electronic)19475918

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ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Zhang, W. B., Cheng, S. Z. D., & Yaszemski, M. J. (2011). Polymeric biomaterials: A history of use in musculoskeletal regenerative and reconstructive medicine. In ACS Symposium Series (Vol. 1080, pp. 165-182). (ACS Symposium Series; Vol. 1080). American Chemical Society. https://doi.org/10.1021/bk-2011-1080.ch011