TY - GEN
T1 - Polymeric biomaterials
T2 - A history of use in musculoskeletal regenerative and reconstructive medicine
AU - Zhang, Wen Bin
AU - Cheng, Stephen Z.D.
AU - Yaszemski, Michael J.
PY - 2011
Y1 - 2011
N2 - This chapter provides an overview of the application of synthetic polymeric biomaterials in musculoskeletal regenerative and reconstructive medicine with selected examples. Hydrogels capable of cell and growth factor delivery were assessed for injectable cartilage tissue engineering. Injectable composite scaffolds incorporating bone morphogenetic protein-2 (BMP-2) were developed to regenerate critical-sized defects in a rat femoral defect model. Advanced scaffold design was achieved by computer aided stereolithography. Nerve tubes with multiple parallel channels were investigated as guidance scaffolds for peripheral nerve and spinal cord regeneration. All of these demonstrated the versatility of synthetic polymers as multifunctional, interactive, and biodegradable bioscaffolds with virtually unlimited possibility for performance optimization through polymer and surface chemistry modification and physical manipulation.
AB - This chapter provides an overview of the application of synthetic polymeric biomaterials in musculoskeletal regenerative and reconstructive medicine with selected examples. Hydrogels capable of cell and growth factor delivery were assessed for injectable cartilage tissue engineering. Injectable composite scaffolds incorporating bone morphogenetic protein-2 (BMP-2) were developed to regenerate critical-sized defects in a rat femoral defect model. Advanced scaffold design was achieved by computer aided stereolithography. Nerve tubes with multiple parallel channels were investigated as guidance scaffolds for peripheral nerve and spinal cord regeneration. All of these demonstrated the versatility of synthetic polymers as multifunctional, interactive, and biodegradable bioscaffolds with virtually unlimited possibility for performance optimization through polymer and surface chemistry modification and physical manipulation.
UR - http://www.scopus.com/inward/record.url?scp=84905512405&partnerID=8YFLogxK
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U2 - 10.1021/bk-2011-1080.ch011
DO - 10.1021/bk-2011-1080.ch011
M3 - Conference contribution
AN - SCOPUS:84905512405
SN - 9780841226777
T3 - ACS Symposium Series
SP - 165
EP - 182
BT - 100+ Years of Plastics. Leo Baekeland and Beyond
PB - American Chemical Society
ER -