Abstract
The incidence of human papillomavirus (HPV) DNA in archival formalin-fixed, paraffin-embedded tissue sections from verrucous carcinoma of the larynx was determined using polymerase chain reaction (PCR) with consensus primers and by in situ hybridization designed to detect HPV types 6/11, 16/18, 31/33/35. HPV DNA was detected in 17 (85%) of 20 tissue samples by PCR; none of the 20 samples were positive for the seven genotype types tested by in situ hybridization. PCR is a valuable tool to detect HPV and therefore will significantly clarify the importance of HPV in squamous mucosal disorders.
Original language | English (US) |
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Pages (from-to) | 416-420 |
Number of pages | 5 |
Journal | Laryngoscope |
Volume | 103 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1993 |
ASJC Scopus subject areas
- Otorhinolaryngology