TY - JOUR
T1 - Polyglucosan body axonal enlargement increases myelin spiral length but not lamellar number
AU - Yoshikawa, Hiroo
AU - Dyck, Peter James
AU - Poduslo, Joseph F.
AU - Giannini, Caterina
N1 - Funding Information:
This research was supported, in part, by center grants from NINCDS (NS 14304) and MDA, and funds from Mayo Foundation, Upton, Whirlpool, and Borchard Funds. Dr. Yoshikawa received support from Hokusetsu General Hospital, Takatsuki-City, Osaka, Japan.
PY - 1990/8
Y1 - 1990/8
N2 - The area of the unrolled myelin sheet of internodes of myelinated fibers (MF) of peripheral nerve is thought to be determined by axonal caliber and internodal length. We studied the effect of a focal increase of axonal caliber due to the deposition of polyglucosan bodies (PGB), amylopectin-like glucose polymers, on number of myelin lamellae (NL), interlamellar distance (periodicity), and myelin spiral length (MSL) from a sural nerve biopsy specimen of a patient with chronic inflammatory demyelinating polyneuropathy. Axonal area, NL, periodicity, and MSL were estimated within internodes of MF above, at, and below PGB. The axon caliber at the level of the PGB was significantly (P < 0.002) increased when the PGB was included. At the PGB, NL and their periodicity were not significantly different from those above or below the PGB. The MSL was significantly longer overlying the PGB than it was in the same internode above or below the PGB. Because slippage or stretching of the myelin sheath as well as movement of molecular constituents of myelin is not likely over large distances, localized biosynthesis and assembly of new myelin may explain this increase of MSL.
AB - The area of the unrolled myelin sheet of internodes of myelinated fibers (MF) of peripheral nerve is thought to be determined by axonal caliber and internodal length. We studied the effect of a focal increase of axonal caliber due to the deposition of polyglucosan bodies (PGB), amylopectin-like glucose polymers, on number of myelin lamellae (NL), interlamellar distance (periodicity), and myelin spiral length (MSL) from a sural nerve biopsy specimen of a patient with chronic inflammatory demyelinating polyneuropathy. Axonal area, NL, periodicity, and MSL were estimated within internodes of MF above, at, and below PGB. The axon caliber at the level of the PGB was significantly (P < 0.002) increased when the PGB was included. At the PGB, NL and their periodicity were not significantly different from those above or below the PGB. The MSL was significantly longer overlying the PGB than it was in the same internode above or below the PGB. Because slippage or stretching of the myelin sheath as well as movement of molecular constituents of myelin is not likely over large distances, localized biosynthesis and assembly of new myelin may explain this increase of MSL.
KW - Axon-Schwann cell interaction
KW - Focal axonal enlargement
KW - Local myelin biosynthesis and assembly
KW - Myelin sheath geometry
KW - Polyglucosan bodies
UR - http://www.scopus.com/inward/record.url?scp=0025151102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025151102&partnerID=8YFLogxK
U2 - 10.1016/0022-510X(90)90186-Q
DO - 10.1016/0022-510X(90)90186-Q
M3 - Article
C2 - 2230827
AN - SCOPUS:0025151102
SN - 0022-510X
VL - 98
SP - 107
EP - 117
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
IS - 1
ER -