Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy

Gianfranco Pasut, Donatella Paolino, Christian Celia, Anna Mero, Adrian Steve Joseph, Joy Wolfram, Donato Cosco, Oddone Schiavon, Haifa Shen, Massimo Fresta

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Pegylation of nanoparticles has been widely implemented in the field of drug delivery to prevent macrophage clearance and increase drug accumulation at a target site. However, the shielding effect of polyethylene glycol (PEG) is usually incomplete and transient, due to loss of nanoparticle integrity upon systemic injection. Here, we have synthesized unique PEG-dendron-phospholipid constructs that form super stealth liposomes (SSLs). A β-glutamic acid dendron anchor was used to attach a PEG chain to several distearoyl phosphoethanolamine lipids, thereby differing from conventional stealth liposomes where a PEG chain is attached to a single phospholipid. This composition was shown to increase liposomal stability, prolong the circulation half-life, improve the biodistribution profile and enhance the anticancer potency of a drug payload (doxorubicin hydrochloride).

Original languageEnglish (US)
Pages (from-to)106-113
Number of pages8
JournalJournal of Controlled Release
Volume199
DOIs
StatePublished - Feb 10 2015
Externally publishedYes

Fingerprint

Liposomes
Phospholipids
Nanoparticles
Pharmaceutical Preparations
Therapeutics
Doxorubicin
Half-Life
Glutamic Acid
Macrophages
Lipids
Injections
dendron

Keywords

  • Cancer therapy
  • Liposome
  • Pegylation
  • Phospholipid
  • Polyethylene glycol

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Medicine(all)

Cite this

Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy. / Pasut, Gianfranco; Paolino, Donatella; Celia, Christian; Mero, Anna; Joseph, Adrian Steve; Wolfram, Joy; Cosco, Donato; Schiavon, Oddone; Shen, Haifa; Fresta, Massimo.

In: Journal of Controlled Release, Vol. 199, 10.02.2015, p. 106-113.

Research output: Contribution to journalArticle

Pasut, Gianfranco ; Paolino, Donatella ; Celia, Christian ; Mero, Anna ; Joseph, Adrian Steve ; Wolfram, Joy ; Cosco, Donato ; Schiavon, Oddone ; Shen, Haifa ; Fresta, Massimo. / Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy. In: Journal of Controlled Release. 2015 ; Vol. 199. pp. 106-113.
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AU - Joseph, Adrian Steve

AU - Wolfram, Joy

AU - Cosco, Donato

AU - Schiavon, Oddone

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