Abstract
Pegylation of nanoparticles has been widely implemented in the field of drug delivery to prevent macrophage clearance and increase drug accumulation at a target site. However, the shielding effect of polyethylene glycol (PEG) is usually incomplete and transient, due to loss of nanoparticle integrity upon systemic injection. Here, we have synthesized unique PEG-dendron-phospholipid constructs that form super stealth liposomes (SSLs). A β-glutamic acid dendron anchor was used to attach a PEG chain to several distearoyl phosphoethanolamine lipids, thereby differing from conventional stealth liposomes where a PEG chain is attached to a single phospholipid. This composition was shown to increase liposomal stability, prolong the circulation half-life, improve the biodistribution profile and enhance the anticancer potency of a drug payload (doxorubicin hydrochloride).
Original language | English (US) |
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Pages (from-to) | 106-113 |
Number of pages | 8 |
Journal | Journal of Controlled Release |
Volume | 199 |
DOIs | |
State | Published - Feb 10 2015 |
Keywords
- Cancer therapy
- Liposome
- Pegylation
- Phospholipid
- Polyethylene glycol
ASJC Scopus subject areas
- Pharmaceutical Science