Polycythemia vera-associated pruritus and its management

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Background Pruritus is a defining feature of polycythemia vera (PV) and is seen in approximately 40% of patients. In most cases, the pruritus is characteristically triggered by contact with water (aquagenic) at any temperature. Materials and methods A detailed MEDLINE search for all English language articles related to PV, PV-associated pruritus and aquagenic pruritus that were published from 1965 till date was carried out. Results Many different treatment options have been tried over the past several decades, including antihistamines, antidepressants, interferon alpha, phlebotomy, phototherapy, iron supplements and myelosuppressive medications, all demonstrating mixed results. Recently, agents that target JAK2 and mammalian target of rapamycin (mTOR) have shown impressive clinical benefit. Conclusion PV-associated pruritus is a major cause of morbidity amongst patients with PV. Antidepressant medications interfering with serotonin uptake are somewhat efficacious. Cytoreductive therapy is reserved for refractory cases. Targeted therapy with JAK2 and mTOR inhibitors offers renewed hope.

Original languageEnglish (US)
Pages (from-to)828-834
Number of pages7
JournalEuropean Journal of Clinical Investigation
Volume40
Issue number9
DOIs
StatePublished - Sep 1 2010

Keywords

  • Myeloproliferative neoplasms
  • polycythemia vera
  • pruritus

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Polycythemia vera-associated pruritus and its management'. Together they form a unique fingerprint.

  • Cite this