Polycystic ovary syndrome and risk of uterine leiomyomata

Lauren A. Wise, Julie R. Palmer, Elizabeth A. Stewart, Lynn Rosenberg

Research output: Contribution to journalArticle

38 Scopus citations


Objective: To examine the association between polycystic ovary syndrome (PCOS) and the risk of uterine leiomyomata (UL). Design: Prospective cohort study. Setting: Participants from the Black Women's Health Study, an ongoing prospective cohort study of African-American women aged 21-69 years in 1995 residing in the United States. Participants completed mailed questionnaires about their health status every 2 years. Patient(s): Premenopausal women with no history of UL at the start of follow-up (N = 23,571). Intervention(s): No interventions were administered. Main Outcome Measure: Incidence of UL among those with and without self-reported, physician-diagnosed PCOS over a 6-year period of follow-up (1997-2003). Medical-record validation in a random subset of UL cases confirmed 96% of diagnoses. Result(s): During 114,373 person-years of follow-up, 3,631 new cases of UL confirmed by ultrasound (N = 2,926) or hysterectomy (N = 705) were reported. After adjustment for potential confounders, the incidence of UL was 65% higher among women with PCOS than women without PCOS (incidence rate ratio, 1.65; 95% confidence interval, 1.21-2.24). The incidence rate ratios remained constant with increasing time after the diagnosis of PCOS. Results were similar when analyses were confined to women reporting a recent Papanicolaou smear, a proxy for a pelvic examination. Conclusion(s): The present study suggests a positive association between PCOS and UL in African-American women.

Original languageEnglish (US)
Pages (from-to)1108-1115
Number of pages8
JournalFertility and Sterility
Issue number5
StatePublished - May 1 2007


  • African-Americans
  • Stein-Leventhal syndrome
  • females
  • leiomyoma
  • polycystic ovaries
  • premenopausal
  • uterine neoplasms

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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