Polycystic kidney disease: Genes, proteins, animal models, disease mechanisms and therapeutic opportunities

Research output: Contribution to journalArticle

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Abstract

An increased understanding of the genetic, molecular and cellular mechanisms responsible for the development of polycystic kidney disease has laid out the foundation for the development of rational therapies. Many animal models where these therapies can be tested are currently available. This review summarizes the rationale for these treatments, the results of preclinical trials and the prospects for clinical trials, some already in early phases of implementation.

Original languageEnglish (US)
Pages (from-to)17-31
Number of pages15
JournalJournal of Internal Medicine
Volume261
Issue number1
DOIs
StatePublished - Jan 1 2007

Keywords

  • Autosomal dominant polycystic kidney disease
  • Autosomal recessive polycystic kidney disease
  • ErbB tyrosine kinase inhibitors
  • Polycystic kidney disease
  • Vasopressin V2 receptor antagonists
  • mTOR inhibitors

ASJC Scopus subject areas

  • Internal Medicine

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