Polyarginine induces an antitumor immune response through binding to toll-like receptor 4

Yong Yang, Joy Wolfram, Xiaohong Fang, Haifa Shen, Mauro Ferrari

Research output: Contribution to journalArticle

14 Scopus citations


A novel function of polyarginine as an activator of the immune system is reported. Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation. Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)1250-1254
Number of pages5
Issue number7
StatePublished - Apr 9 2014
Externally publishedYes



  • cancer immunotherapy
  • polyarginine
  • single-molecule fluorescence imaging
  • single-molecule force measurement

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Engineering (miscellaneous)

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