Polyarginine induces an antitumor immune response through binding to toll-like receptor 4

Yong Yang; Joy Wolfram; Xiaohong Fang; Haifa Shen; Mauro Ferrari

doi:10.1002/smll.201302887

Polyarginine induces an antitumor immune response through binding to toll-like receptor 4

Yong Yang, Joy Wolfram, Xiaohong Fang, Haifa Shen, Mauro Ferrari

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A novel function of polyarginine as an activator of the immune system is reported. Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation. Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy.

Original language	English (US)
Pages (from-to)	1250-1254
Number of pages	5
Journal	Small
Volume	10
Issue number	7
DOIs	https://doi.org/10.1002/smll.201302887
State	Published - Apr 9 2014

Keywords

cancer immunotherapy
polyarginine
single-molecule fluorescence imaging
single-molecule force measurement

ASJC Scopus subject areas

Biotechnology
Biomaterials
General Chemistry
General Materials Science

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10.1002/smll.201302887

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abstract = "A novel function of polyarginine as an activator of the immune system is reported. Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation. Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy.",

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AU - Wolfram, Joy

AU - Fang, Xiaohong

AU - Shen, Haifa

AU - Ferrari, Mauro

PY - 2014/4/9

Y1 - 2014/4/9

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AB - A novel function of polyarginine as an activator of the immune system is reported. Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation. Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy.

KW - cancer immunotherapy

KW - polyarginine

KW - single-molecule fluorescence imaging

KW - single-molecule force measurement

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Polyarginine induces an antitumor immune response through binding to toll-like receptor 4

Abstract

Keywords

ASJC Scopus subject areas

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