Polyarginine induces an antitumor immune response through binding to toll-like receptor 4

Yong Yang, Joy Wolfram, Xiaohong Fang, Haifa Shen, Mauro Ferrari

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A novel function of polyarginine as an activator of the immune system is reported. Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation. Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)1250-1254
Number of pages5
JournalSmall
Volume10
Issue number7
DOIs
StatePublished - Apr 9 2014
Externally publishedYes

Fingerprint

Toll-Like Receptor 4
Chemical activation
Molecules
Dimerization
Force measurement
Immune system
Tumors
Fluorescence
Imaging techniques
Optical Imaging
Immunotherapy
Immune System
Neoplasms
polyarginine
Growth

Keywords

  • cancer immunotherapy
  • polyarginine
  • single-molecule fluorescence imaging
  • single-molecule force measurement

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Engineering (miscellaneous)

Cite this

Polyarginine induces an antitumor immune response through binding to toll-like receptor 4. / Yang, Yong; Wolfram, Joy; Fang, Xiaohong; Shen, Haifa; Ferrari, Mauro.

In: Small, Vol. 10, No. 7, 09.04.2014, p. 1250-1254.

Research output: Contribution to journalArticle

Yang, Yong ; Wolfram, Joy ; Fang, Xiaohong ; Shen, Haifa ; Ferrari, Mauro. / Polyarginine induces an antitumor immune response through binding to toll-like receptor 4. In: Small. 2014 ; Vol. 10, No. 7. pp. 1250-1254.
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