Poly(ϵ-caprolactone) Dendrimer Cross-Linked via Metal-Free Click Chemistry: Injectable Hydrophobic Platform for Tissue Engineering

Xifeng Liu, A. Lee Miller, Kevin A. Fundora, Michael J Yaszemski, Lichun Lu

Research output: Contribution to journalArticle

21 Scopus citations


The fabrication of injectable self-cross-linkable hyperbranched poly(ϵ-caprolactone) (hyPCL) formulation using metal-free click chemistry was reported. The cross-linking between hyPCL32-(1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-ylmethanol (hyPCL32-BCN) and hyPCL32-azide (hyPCL32-N3) components was proceeded via strain-promoted alkyne-azide cycloaddition (SPAAC) click reaction. Cross-linking was tested to proceed effectively with the exclusion of any toxic cross-linking agents. Strong mechanical properties and excellent biocompatibility were demonstrated for the cross-linked substrates. These newly synthesized dendrimers may have broad applications in tissue engineering such as bone defect repair. In addition, the introduction of metal-free click chemistry to hydrophobic polymers provides an attractive new strategy for developing injectable stiff polymer formulations besides hydrogels for biomedical applications.

Original languageEnglish (US)
Pages (from-to)1261-1265
Number of pages5
JournalACS Macro Letters
Issue number11
StatePublished - Nov 15 2016


ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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