Point spread function deconvolution in 3D micro-CT angiography for multiscale vascular tree separation

S. T. Witt, C. H. Riedel, M. Goessl, M. S. Chmelik, E. L. Ritman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)

Abstract

Micro-CT angiography of small laboratory mammal organs visualizes vascular branches on a large range of scales, ranging from root-level branches (∼ 1 mm) to endarteriolar vessels (10-40 μm). Multiscale vascular tree segmentation is facilitated by the ability to set a single grayscale threshold value for vessels of all generation levels. Due to the non-ideal modulation transfer function (MTF) of the imaging system, object contrast varies significantly with scale, and the definition of a grayscale threshold for vessel segmentation becomes a problem. We found that performing a point spread function (PSF) deconvolution on the micro-CT projection images significantly reduces the thresholding problem in terms of restoring the smallest vessels' grayscale and delineation. The increased noise from performing a PSF deconvolution will not have a significant effect on the overall signal-to-noise ratio of the images. The PSF deconvolution was successful only when it accommodated the spatial variation of the PSF.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsM.J. Yaffe, L.E. Antonuk
Pages720-727
Number of pages8
Volume5030 II
DOIs
StatePublished - 2003
EventMedical Imaging 2003: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 16 2003Feb 18 2003

Other

OtherMedical Imaging 2003: Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/16/032/18/03

Fingerprint

Angiography
angiography
Optical transfer function
Deconvolution
point spread functions
vessels
mammals
thresholds
delineation
modulation transfer function
Mammals
organs
signal to noise ratios
Imaging systems
projection
Signal to noise ratio

Keywords

  • 3D micro-CT imaging
  • MTF
  • Multiscale vascular tree representation
  • PSF
  • Volume scanning

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Witt, S. T., Riedel, C. H., Goessl, M., Chmelik, M. S., & Ritman, E. L. (2003). Point spread function deconvolution in 3D micro-CT angiography for multiscale vascular tree separation. In M. J. Yaffe, & L. E. Antonuk (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5030 II, pp. 720-727) https://doi.org/10.1117/12.480232

Point spread function deconvolution in 3D micro-CT angiography for multiscale vascular tree separation. / Witt, S. T.; Riedel, C. H.; Goessl, M.; Chmelik, M. S.; Ritman, E. L.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / M.J. Yaffe; L.E. Antonuk. Vol. 5030 II 2003. p. 720-727.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Witt, ST, Riedel, CH, Goessl, M, Chmelik, MS & Ritman, EL 2003, Point spread function deconvolution in 3D micro-CT angiography for multiscale vascular tree separation. in MJ Yaffe & LE Antonuk (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5030 II, pp. 720-727, Medical Imaging 2003: Physics of Medical Imaging, San Diego, CA, United States, 2/16/03. https://doi.org/10.1117/12.480232
Witt ST, Riedel CH, Goessl M, Chmelik MS, Ritman EL. Point spread function deconvolution in 3D micro-CT angiography for multiscale vascular tree separation. In Yaffe MJ, Antonuk LE, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5030 II. 2003. p. 720-727 https://doi.org/10.1117/12.480232
Witt, S. T. ; Riedel, C. H. ; Goessl, M. ; Chmelik, M. S. ; Ritman, E. L. / Point spread function deconvolution in 3D micro-CT angiography for multiscale vascular tree separation. Proceedings of SPIE - The International Society for Optical Engineering. editor / M.J. Yaffe ; L.E. Antonuk. Vol. 5030 II 2003. pp. 720-727
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