Point-of-care optical tool to detect early stage of hemorrhage and shock

Rajan S. Gurjar, Suzannah L. Riccardi, Blair D. Johnson, Christopher P. Johnson, Norman A. Paradis, Michael J. Joyner, David E. Wolf

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


There is a critical unmet clinical need for a device that can monitor and predict the onset of shock: hemorrhagic shock or bleeding to death, septic shock or systemic infection, and cardiogenic shock or blood flow and tissue oxygenation impairment due to heart attack. Together these represent 141 M patients per year. We have developed a monitor for shock based on measuring blood flow in peripheral (skin) capillary beds using diffuse correlation spectroscopy, a form of dynamic light scattering, and have demonstrated proof-of-principle both in pigs and humans. Our results show that skin blood flow measurement, either alone or in conjunction with other hemodynamic properties such as heart rate variability, pulse pressure variability, and tissue oxygenation, can meet this unmet need in a small self-contained patch-like device in conjunction with a hand-held processing unit. In this paper we describe and discuss the experimental work and the multivariate statistical analysis performed to demonstrate proof-of-principle of the concept.

Original languageEnglish (US)
Title of host publicationOptical Diagnostics and Sensing XIV
Subtitle of host publicationToward Point-of-Care Diagnostics
ISBN (Print)9780819498649
StatePublished - 2014
EventOptical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics - San Francisco, CA, United States
Duration: Feb 3 2014Feb 6 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherOptical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics
Country/TerritoryUnited States
CitySan Francisco, CA


  • Diffuse Correlation
  • Hemorrhage
  • Point-of-Care

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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