Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia

Medicine & Life Sciences

• Uromodulin 90%
• Hyperuricemia 74%
• Point Mutation 58%
• Transgenic Mice 53%
• Kidney 32%
• Juvenile gout 22%
• Mutation 20%
• Allantoin 19%
• Extremities 17%
• Urine 17%
• Oliguria 16%
• Polyuria 15%
• Unfolded Protein Response 15%
• Gout 14%
• Kidney Diseases 12%
• Uric Acid 12%
• Cysteine 11%
• Renal Insufficiency 10%
• Creatinine 9%
• Apoptosis 7%
• Serum 5%
• Genes 4%
• Therapeutics 1%

Agriculture & Biology

• hyperuricemia 100%
• point mutation 66%
• genetically modified organisms 45%
• kidneys 43%
• mice 34%
• proteins 20%
• kidney diseases 19%
• mutation 15%
• limbs (animal) 14%
• pathogenesis 13%
• urine 12%
• gout 11%
• renal failure 10%
• allantoin 10%
• unfolded protein response 10%
• renal function 9%
• proximal tubules 9%
• uric acid 8%
• creatinine 7%
• apoptosis 6%
• cysteine 6%
• therapeutics 5%
• gene expression 4%
• mutants 4%
• testing 2%
• genes 2%

Chemical Compounds

• Mutation 50%
• Allantoin 30%
• Catabolic 26%
• Protein 24%
• Creatinine 24%
• Clearance 21%
• Uric Acid 21%
• Cysteine 17%