POEMS Syndrome

Diagnosis and Investigative Work-up

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

POEMS syndrome is a rare paraneoplastic syndrome secondary to a plasma cell dyscrasia. Recognition of a combination of peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasmaproliferative disorder, skin changes, papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis, and Castleman disease is the first step in managing the disease. Increased blood levels of vascular endothelial growth factor are usually confirmatory. This rare disorder should not be missed, especially if the patient has a putative diagnosis of chronic inflammatory polyradiculoneuropathy, a lambda restricted monoclonal gammopathy, and thrombocytosis, and is not responding as expected to immunomodulatory therapy commonly used for chronic inflammatory polyradiculoneuropathy.

Original languageEnglish (US)
Pages (from-to)119-139
Number of pages21
JournalHematology/Oncology Clinics of North America
Volume32
Issue number1
DOIs
StatePublished - Feb 1 2018

Fingerprint

POEMS Syndrome
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Thrombocytosis
Paraproteinemias
Giant Lymph Node Hyperplasia
Paraneoplastic Syndromes
Papilledema
Immunomodulation
Peripheral Nervous System Diseases
Vascular Endothelial Growth Factor A
Bone and Bones
Skin

Keywords

  • Castleman disease
  • Chronic inflammatory polyradiculoneuropathy
  • Paraneoplastic
  • Plasma cell disorder

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

POEMS Syndrome : Diagnosis and Investigative Work-up. / Dispenzieri, Angela; Kourelis, Taxiarchis; Buadi, Francis.

In: Hematology/Oncology Clinics of North America, Vol. 32, No. 1, 01.02.2018, p. 119-139.

Research output: Contribution to journalReview article

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