POEMS Syndrome: Diagnosis and Investigative Work-up

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

POEMS syndrome is a rare paraneoplastic syndrome secondary to a plasma cell dyscrasia. Recognition of a combination of peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasmaproliferative disorder, skin changes, papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis, and Castleman disease is the first step in managing the disease. Increased blood levels of vascular endothelial growth factor are usually confirmatory. This rare disorder should not be missed, especially if the patient has a putative diagnosis of chronic inflammatory polyradiculoneuropathy, a lambda restricted monoclonal gammopathy, and thrombocytosis, and is not responding as expected to immunomodulatory therapy commonly used for chronic inflammatory polyradiculoneuropathy.

Original languageEnglish (US)
Pages (from-to)119-139
Number of pages21
JournalHematology/Oncology Clinics of North America
Volume32
Issue number1
DOIs
StatePublished - Feb 1 2018

Keywords

  • Castleman disease
  • Chronic inflammatory polyradiculoneuropathy
  • Paraneoplastic
  • Plasma cell disorder

ASJC Scopus subject areas

  • Hematology
  • Oncology

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