POEMS syndrome and Castleman’s disease

Angela Dispenzieri

doi:10.1007/978-1-4419-6848-7_3

POEMS syndrome and Castleman’s disease

Angela Dispenzieri

Hematology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

POEMS syndrome is a rare paraneoplastic syndrome due to an underlying plasma cell disorder. The dominant feature is typically peripheral neuropathy, and the hematologic manifestations can be subtle leading to delayed diagnosis. Although the mechanism of disease is not well understood, the disease is very treatable, and survival is typically excellent. Castleman’s disease (CD) can occur with and without POEMS syndrome. Patients with unicentric CD have an excellent prognosis with local therapies; outcomes are less good, and therapies are less well established for the patients with multicentric CD with the exception of interleukin-6 and interleukin-6 receptor antibodies, which are useful in a subset of patients.

Original language	English (US)
Title of host publication	Biology and Management of Unusual Plasma Cell Dyscrasias
Publisher	Springer New York
Pages	41-69
Number of pages	29
ISBN (Electronic)	9781441968487
ISBN (Print)	9781441968470
DOIs	https://doi.org/10.1007/978-1-4419-6848-7_3
State	Published - Jan 1 2016

Keywords

Castleman’s disease
Monoclonal gammopathy of undetermined significance
Multiple myeloma
Osteosclerotic myeloma
POEMS syndrome
Paraneoplastic syndrome
Vascular endothelial growth factor

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-1-4419-6848-7_3

Cite this

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abstract = "POEMS syndrome is a rare paraneoplastic syndrome due to an underlying plasma cell disorder. The dominant feature is typically peripheral neuropathy, and the hematologic manifestations can be subtle leading to delayed diagnosis. Although the mechanism of disease is not well understood, the disease is very treatable, and survival is typically excellent. Castleman{\textquoteright}s disease (CD) can occur with and without POEMS syndrome. Patients with unicentric CD have an excellent prognosis with local therapies; outcomes are less good, and therapies are less well established for the patients with multicentric CD with the exception of interleukin-6 and interleukin-6 receptor antibodies, which are useful in a subset of patients.",

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POEMS syndrome and Castleman’s disease

Abstract

Keywords

ASJC Scopus subject areas

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