POEMS syndrome is a rare paraneoplastic condition due to an underlying plasma cell disorder that presents with a demyelinating peripheral neuropathy. The syndrome is most often associated with osteosclerotic bone lesions and high vascular endothelial growth factor. The other symptoms and signs would appear to be unrelated if one does not consider the diagnosis of this fascinating syndrome. Without adequate treatment, POEMS syndrome is progressive, disabling, and life-threatening. With treatment the prognosis is excellent when drugs from a myeloma armamentarium are employed.