Ploidy status rarely changes in myeloma patients at disease progression

W. J. Chng, J. M. Winkler, P. R. Greipp, S. M. Jalal, Peter Leif Bergsagel, Marta Chesi, M. C. Trendle, G. J. Ahmann, K. Henderson, E. Blood, M. M. Oken, A. Hulbert, S. A Van Wier, R. Santana-Dávila, R. A. Kyle, Morie Gertz, Martha Lacy, Angela Dispenzieri, Rafael Fonseca

Research output: Contribution to journalArticle

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Abstract

Hyperdiploid and non-hyperdiploid multiple myeloma represents distinct biological entities characterized by different patterns of genetic changes. We sought to determine whether ploidy category (non-hyperdiploid versus hyperdiploid) remains stable over time from diagnosis to progression. Of the 43 patients studied (39 by flow cytometry DNA index and 4 by a FISH-based index), only five (12%) altered their ploidy status at progression. In three of these patients, the change may possibly be attributable to technical artifacts because of the low absolute change in DNA index. For those who retain their ploidy subtypes, the DNA index change minimally (3.75 ± 4.87%). It would appear that the initiating genetic events underlying hyperdiploid and non-hyperdiploid MM that marks them out as distinct entities continue to dominate and persist during disease evolution and progression.

Original languageEnglish (US)
Pages (from-to)266-271
Number of pages6
JournalLeukemia Research
Volume30
Issue number3
DOIs
StatePublished - Mar 2006

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Polyploidy
Ploidies
Disease Progression
DNA
Multiple Myeloma
Artifacts
Flow Cytometry

Keywords

  • Disease progression
  • DNA index
  • Flow cytometry
  • Myeloma
  • Ploidy

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Ploidy status rarely changes in myeloma patients at disease progression. / Chng, W. J.; Winkler, J. M.; Greipp, P. R.; Jalal, S. M.; Bergsagel, Peter Leif; Chesi, Marta; Trendle, M. C.; Ahmann, G. J.; Henderson, K.; Blood, E.; Oken, M. M.; Hulbert, A.; Wier, S. A Van; Santana-Dávila, R.; Kyle, R. A.; Gertz, Morie; Lacy, Martha; Dispenzieri, Angela; Fonseca, Rafael.

In: Leukemia Research, Vol. 30, No. 3, 03.2006, p. 266-271.

Research output: Contribution to journalArticle

Chng, WJ, Winkler, JM, Greipp, PR, Jalal, SM, Bergsagel, PL, Chesi, M, Trendle, MC, Ahmann, GJ, Henderson, K, Blood, E, Oken, MM, Hulbert, A, Wier, SAV, Santana-Dávila, R, Kyle, RA, Gertz, M, Lacy, M, Dispenzieri, A & Fonseca, R 2006, 'Ploidy status rarely changes in myeloma patients at disease progression', Leukemia Research, vol. 30, no. 3, pp. 266-271. https://doi.org/10.1016/j.leukres.2005.07.004
Chng, W. J. ; Winkler, J. M. ; Greipp, P. R. ; Jalal, S. M. ; Bergsagel, Peter Leif ; Chesi, Marta ; Trendle, M. C. ; Ahmann, G. J. ; Henderson, K. ; Blood, E. ; Oken, M. M. ; Hulbert, A. ; Wier, S. A Van ; Santana-Dávila, R. ; Kyle, R. A. ; Gertz, Morie ; Lacy, Martha ; Dispenzieri, Angela ; Fonseca, Rafael. / Ploidy status rarely changes in myeloma patients at disease progression. In: Leukemia Research. 2006 ; Vol. 30, No. 3. pp. 266-271.
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