Platypnea-orthodeoxia syndrome: Diagnostic challenge and the importance of heightened clinical suspicion

Stanislav Henkin, Sara Negrotto, Peter M. Pollak, Michael W. Cullen, D. Fearghas O’Cochlain, R. Scott Wright

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Platypnea-orthodeoxia syndrome is an uncommon condition of positional dyspnea and hypoxemia; symptoms occur when the patient is upright and resolve with recumbency. Causes can be broadly categorized into 4 groups: intracardiac shunting, pulmonary shunting, ventilation-perfusion mismatch, or a combination of these. Platypnea-orthodeoxia syndrome should be suspected when normal arterial oxygen saturations are recorded while an individual is supine, followed by abrupt declines in those saturations when upright. Further investigations with use of imaging and cardiac catheterization aid in the evaluation. When platypnea-orthodeoxia syndrome is due to intracardiac shunting without pulmonary hypertension, intracardiac shunt closure can be curative. In this article, we report a case of platypnea-orthodeoxia syndrome in an 83-year-old woman who was successfully treated by means of percutaneous transcatheter closure of an atrial septal defect.

Original languageEnglish (US)
Pages (from-to)498-501
Number of pages4
JournalTexas Heart Institute Journal
Volume42
Issue number5
DOIs
StatePublished - Oct 1 2015

Fingerprint

Pulmonary Ventilation
Atrial Heart Septal Defects
Cardiac Catheterization
Pulmonary Hypertension
Dyspnea
Perfusion
Oxygen
Hypoxia

Keywords

  • Aged, 80 and over
  • Atrial septal defect
  • Cardiac platypnea-orthodeoxia syndrome
  • Dyspnea/etiology/physiopathology
  • Foramen ovale, patent
  • Heart septal defects, atrial/complications
  • Oxygen/blood
  • Posture/physiology
  • Septal occluder device
  • Supine position

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Henkin, S., Negrotto, S., Pollak, P. M., Cullen, M. W., O’Cochlain, D. F., & Scott Wright, R. (2015). Platypnea-orthodeoxia syndrome: Diagnostic challenge and the importance of heightened clinical suspicion. Texas Heart Institute Journal, 42(5), 498-501. https://doi.org/10.14503/THIJ-14-4596

Platypnea-orthodeoxia syndrome : Diagnostic challenge and the importance of heightened clinical suspicion. / Henkin, Stanislav; Negrotto, Sara; Pollak, Peter M.; Cullen, Michael W.; O’Cochlain, D. Fearghas; Scott Wright, R.

In: Texas Heart Institute Journal, Vol. 42, No. 5, 01.10.2015, p. 498-501.

Research output: Contribution to journalArticle

Henkin, S, Negrotto, S, Pollak, PM, Cullen, MW, O’Cochlain, DF & Scott Wright, R 2015, 'Platypnea-orthodeoxia syndrome: Diagnostic challenge and the importance of heightened clinical suspicion', Texas Heart Institute Journal, vol. 42, no. 5, pp. 498-501. https://doi.org/10.14503/THIJ-14-4596
Henkin, Stanislav ; Negrotto, Sara ; Pollak, Peter M. ; Cullen, Michael W. ; O’Cochlain, D. Fearghas ; Scott Wright, R. / Platypnea-orthodeoxia syndrome : Diagnostic challenge and the importance of heightened clinical suspicion. In: Texas Heart Institute Journal. 2015 ; Vol. 42, No. 5. pp. 498-501.
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