We tested the hypothesis that donor factors influence the outcome of platelet transfusion independent of patient factors. Apheresis concentrates from 23 donors who yielded double products were transfused to 46 pairs of recipients with hematological malignancies and thrombocytopenia. Availability determined whether a recipient received ABO identical or non-ABO identical transfusion. The recovery of platelet transfusion was measured by the corrected count increment (CCI) and percentage platelet recovery (PPR) at 1, 4 and 24 hours post-transfusion. For all recipient pairs the difference between the CCI and PPR of the ABO-identical transfusion and that of the ABO non-identical transfusion was significant at 1 hour (CCI: p=0.023 and PPR: p=0.027). However, recoveries in the ABO-identical cohort ranged from 0.05 to 0.65 of platelets transfused, as wide as that of the non-identical recipients, and there was a tight correlation in recovery between pairs of recipients in which both were ABO identical, for either the CCI (r=0.9, p=0.005) or PPR (r=0.9, p=0.003) at 1 hour. We conclude that 1. ABO match has a significant impact on recovery of transfused platelets in vivo independent of patient factors 2. That donor intrinsic factors other than ABO match have an equivalent or greater impact.
|Original language||English (US)|
|Issue number||11 PART II|
|State||Published - Dec 1 2000|
ASJC Scopus subject areas
- Cell Biology