Platelet recovery in abo identical versus non-identical transfusions: A prospective study

Teresa Jimenez, Sachin B. Patel, Alvaro A. Pineda, Ayalew Tefferi, Whyte G. Owen

Research output: Contribution to journalArticle

Abstract

We tested the hypothesis that donor factors influence the outcome of platelet transfusion independent of patient factors. Apheresis concentrates from 23 donors who yielded double products were transfused to 46 pairs of recipients with hematological malignancies and thrombocytopenia. Availability determined whether a recipient received ABO identical or non-ABO identical transfusion. The recovery of platelet transfusion was measured by the corrected count increment (CCI) and percentage platelet recovery (PPR) at 1, 4 and 24 hours post-transfusion. For all recipient pairs the difference between the CCI and PPR of the ABO-identical transfusion and that of the ABO non-identical transfusion was significant at 1 hour (CCI: p=0.023 and PPR: p=0.027). However, recoveries in the ABO-identical cohort ranged from 0.05 to 0.65 of platelets transfused, as wide as that of the non-identical recipients, and there was a tight correlation in recovery between pairs of recipients in which both were ABO identical, for either the CCI (r=0.9, p=0.005) or PPR (r=0.9, p=0.003) at 1 hour. We conclude that 1. ABO match has a significant impact on recovery of transfused platelets in vivo independent of patient factors 2. That donor intrinsic factors other than ABO match have an equivalent or greater impact.

Original languageEnglish (US)
JournalBlood
Volume96
Issue number11 PART II
StatePublished - 2000

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Platelets
Blood Platelets
Prospective Studies
Recovery
Platelet Transfusion
Tissue Donors
Intrinsic Factor
Blood Component Removal
Hematologic Neoplasms
Thrombocytopenia
Availability

ASJC Scopus subject areas

  • Hematology

Cite this

Jimenez, T., Patel, S. B., Pineda, A. A., Tefferi, A., & Owen, W. G. (2000). Platelet recovery in abo identical versus non-identical transfusions: A prospective study. Blood, 96(11 PART II).

Platelet recovery in abo identical versus non-identical transfusions : A prospective study. / Jimenez, Teresa; Patel, Sachin B.; Pineda, Alvaro A.; Tefferi, Ayalew; Owen, Whyte G.

In: Blood, Vol. 96, No. 11 PART II, 2000.

Research output: Contribution to journalArticle

Jimenez, T, Patel, SB, Pineda, AA, Tefferi, A & Owen, WG 2000, 'Platelet recovery in abo identical versus non-identical transfusions: A prospective study', Blood, vol. 96, no. 11 PART II.
Jimenez, Teresa ; Patel, Sachin B. ; Pineda, Alvaro A. ; Tefferi, Ayalew ; Owen, Whyte G. / Platelet recovery in abo identical versus non-identical transfusions : A prospective study. In: Blood. 2000 ; Vol. 96, No. 11 PART II.
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